ArticleFrontiers in behavioral neuroscience2013
Altered anxiety-related and abnormal social behaviors in rats exposed to early life seizures.
Article in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- Rapamycin and Minocycline Treatment Does Not Rescue Behavioral and Molecular Changes Induced by Early-Life Seizures in Female Mice.NeuroSci · 2026Article
- A Two-Hit Approach Inducing Flurothyl Seizures in Fmr1 Knockout Mice Impacts Anxiety and Repetitive Behaviors.Brain sciences · 2024Article
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- Repurposing dimethyl fumarate as an antiepileptogenic and disease-modifying treatment for drug-resistant epilepsy.Journal of translational medicine · 2023Article
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- The outcome of early life status epilepticus-lessons from laboratory animals.Epilepsia open · 2023Article
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- Learning Deficits and Attenuated Adaptive Stress Response After Early-Life Seizures in Zebrafish.Frontiers in neuroscience · 2022Article
- Shank3 Deficiency is Associated With Altered Profile of Neurotransmission Markers in Pups and Adult Mice.Neurochemical research · 2021Article
- mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus.Journal of neurodevelopmental disorders · 2021Article
- The Protective Role of E-64d in Hippocampal Excitotoxic Neuronal Injury Induced by Glutamate in HT22 Hippocampal Neuronal Cells.Neural plasticity · 2021Article
- Dataset on sociability, cognitive function, gene and protein expression of molecules involved in social behavior, reward system and synapse function followingData in brief · 2020Article
- Increased Endocannabinoid Signaling Reduces Social Motivation in Intact Rats and Does Not Affect Animals Submitted to Early-Life Seizures.Frontiers in behavioral neuroscience · 2020Article
- A single early-life seizure results in long-term behavioral changes in the adult Fmr1 knockout mouse.Epilepsy research · 2019Article
- Late Effects ofRadiation research · 2019Article
- Reduction of Mitophagy-Related Oxidative Stress and Preservation of Mitochondria Function Using Melatonin Therapy in an HT22 Hippocampal Neuronal Cell Model of Glutamate-Induced Excitotoxicity.Frontiers in endocrinology · 2019Article
- Regulation of seizure-induced MeCP2 Ser421 phosphorylation in the developing brain.Neurobiology of disease · 2018Article
- Effect of diazepam on sociability of rats submitted to neonatal seizures.Data in brief · 2016Article
- Enhanced long term potentiation and decreased AMPA receptor desensitization in the acute period following a single kainate induced early life seizure.Neurobiology of disease · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonatal seizures are the most common manifestation of neurological dysfunction in the neonate. The prognosis of neonatal seizures is highly variable, and the controversy remains whether the severity, duration, or frequency of seizures may contribute to brain damage independently of its etiology. Animal data indicates that seizures during development are associated with a high probability of long-term adverse effects such as learning and memory impairment, behavioral changes and even epilepsy, which is strongly age dependent, as well as the severity, duration, and frequency of seizures. In preliminary studies, we demonstrated that adolescent male rats exposed to one-single neonatal status epilepticus (SE) episode showed social behavior impairment, and we proposed the model as relevant for studies of developmental disorders. Based on these facts, the goal of this study was to verify the existence of a persistent deficit and if the anxiety-related behavior could be associated with that impairment. To do so, male Wistar rats at 9 days postnatal were submitted to a single episode of SE by pilocarpine injection (380 mg/kg, i.p.) and control animals received saline (0.9%, 0.1 mL/10 g). It was possible to demonstrate that in adulthood, animals exposed to neonatal SE displayed low preference for social novelty, anxiety-related behavior, and increased stereotyped behavior in anxiogenic environment with no locomotor activity changes. On the balance, these data suggests that neonatal SE in rodents leads to altered anxiety-related and abnormal social behaviors.
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