ArticleInternational journal of biomedical science : IJBS2013
The biology of the glutamatergic system and potential role in migraine.
Article in International journal of biomedical science : IJBS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- PathVar: A Customisable NGS Variant Calling Algorithm Implicates Novel Candidate Genes and Pathways in Hemiplegic Migraine.Clinical genetics · 2025Article
- Association between liver enzyme levels and prevalence of migraine: the atherosclerosis risk in communities study.Therapeutic advances in neurological disorders · 2025Article
- Influences of Genetic and Environmental Factors on Chronic Migraine: A Narrative Review.Current pain and headache reports · 2024Review
- Mechanism of Traditional Chinese Medicine in Treating Migraine: A Comprehensive Review.Journal of pain research · 2024Review
- Multi-omic analyses of triptan-treated migraine attacks gives insight into molecular mechanisms.Scientific reports · 2023Article
- Cluster headache and kynurenines.The journal of headache and pain · 2023Article
- Biomarkers of Migraine: An Integrated Evaluation of Preclinical and Clinical Findings.International journal of molecular sciences · 2023Review
- Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain.International journal of molecular sciences · 2022Article
- Identification of Novel Genetic Variants Associated with Insomnia and Migraine Comorbidity.Nature and science of sleep · 2022Article
- Characterizing the Retinal Phenotype of the Thy1-h[A30P]α-syn Mouse Model of Parkinson's Disease.Frontiers in neuroscience · 2021Article
- Role of Glutamatergic Excitotoxicity in Neuromyelitis Optica Spectrum Disorders.Frontiers in cellular neuroscience · 2019Review
- Studies on the Mechanism of Glutamate Metabolism in NTG-Induced Migraine Rats Treated with DCXF.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Interactions between the Kynurenine and the Endocannabinoid System with Special Emphasis on Migraine.International journal of molecular sciences · 2017Review
- Riboflavin Has Neuroprotective Potential: Focus on Parkinson's Disease and Migraine.Frontiers in neurology · 2017Review
- Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model.Scientific reports · 2016Article
- Migraine genetics: current findings and future lines of research.Neurogenetics · 2015Article
- Altered serum levels of kynurenine metabolites in patients affected by cluster headache.The journal of headache and pain · 2015Article
- Case-control study of GRIA1 and GRIA3 gene variants in migraine.The journal of headache and pain · 2015Article
- New insights into pathophysiology of vestibular migraine.Frontiers in neurology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is a common genetically linked neurovascular disorder. Approximately ∼12% of the Caucasian population are affected including 18% of adult women and 6% of adult men (1, 2). A notable female bias is observed in migraine prevalence studies with females affected ∼3 times more than males and is credited to differences in hormone levels arising from reproductive achievements. Migraine is extremely debilitating with wide-ranging socioeconomic impact significantly affecting people's health and quality of life. A number of neurotransmitter systems have been implicated in migraine, the most studied include the serotonergic and dopaminergic systems. Extensive genetic research has been carried out to identify genetic variants that may alter the activity of a number of genes involved in synthesis and transport of neurotransmitters of these systems. The biology of the Glutamatergic system in migraine is the least studied however there is mounting evidence that its constituents could contribute to migraine. The discovery of antagonists that selectively block glutamate receptors has enabled studies on the physiologic role of glutamate, on one hand, and opened new perspectives pertaining to the potential therapeutic applications of glutamate receptor antagonists in diverse neurologic diseases. In this brief review, we discuss the biology of the Glutamatergic system in migraine outlining recent findings that support a role for altered Glutamatergic neurotransmission from biochemical and genetic studies in the manifestation of migraine and the implications of this on migraine treatment.
Indexed as
Identifiers
23675283PMC3644410W2026284037What OpenQuestion holds
Registered trials
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