ArticleInternational journal of biomedical science : IJBS2006
Chiral drugs: an overview.
Article in International journal of biomedical science : IJBS, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 272 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
272 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Exploring the Impact of Chirality of Synthetic Cannabinoids and Cathinones: A Systematic Review on Enantioresolution Methods and Enantioselectivity Studies.International journal of molecular sciences · 2025Pooled it
- A Systematic Review on Dementia and Translocator Protein (TSPO): When Nuclear Medicine Highlights an Underlying Expression.Biomolecules · 2023Pooled it
- Evaluation of Trials Comparing Single-Enantiomer Drugs to Their Racemic Precursors: A Systematic Review.JAMA network open · 2021Pooled it
- Integrated 1D-LC-HRMS and Heart-Cutting 2D-LC-MS for Impurity Profiling and Chiral Separation of Mitiglinide Drug Substance.Rapid communications in mass spectrometry : RCM · 2026Article
- Enantiomer-Resolved Biological Profiling and Chiral Developability Assessment of Novel Naphthylethyl Thioureas.Pharmaceutics · 2026Article
- Rethinking Chiral Decision-Making in Pharmaceutical Analysis: The Emerging Role of Artificial Intelligence.Chirality · 2026Review
- Pharmacokinetics and Efficacy of a Cyanide-Neutralizing [MoJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Article
- Synthesis of 2,3-(Diheterocyclyl)Propanoic Acid Esters as New Building Blocks via Complementary Meldrum's Acid and Aza-Michael Strategies.Molecules (Basel, Switzerland) · 2026Article
- Chiral-Modified Nucleoside Analogues: From Bioactivity to Therapeutic Applications.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Enantiodifferentiation of α-Arylacetic Acid and Thiohydantoin Derivatives by NMR Using Thiourea-Based Chiral Solvating Agents.Molecules (Basel, Switzerland) · 2026Article
- Enhanced Enantioselective Optical Trapping Enabled by Longitudinal Mie Resonances in Silicon Nanodisks.Nanophotonics (Berlin, Germany) · 2026Article
- Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods.Chirality · 2026Review
- Enantioselective Separation and Negative Transport of Chiral Particles via Optical Needle Fields.Nanophotonics (Berlin, Germany) · 2026Article
- Chiral Coumarin Enantiomers From Prangos pabularia Roots: Absolute Configuration, Tyrosinase Activation, and Anti-Vitiligo Potential in B16F10 Cells.Chemistry & biodiversity · 2026Article
- Enantioseparation of proton pump inhibitors using multimodal chiral cation exchangers.Analytical and bioanalytical chemistry · 2026Article
- Stereoselective, sex-dependent 5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Chiral Transformation of a Nanostructured Silver Film by Illumination with Circularly Polarized Light.ACS nano · 2026Article
- Conformational chirality in buckled molecular silicenes: a precursor for chiral magnets.RSC advances · 2026Article
- Chiral Ligand-Protected Gold Nanoclusters as Biosensors for Small Chiral Biomolecules: A Computational Study.ACS nano · 2026Article
- Double Salts and Racemate in Mefloquine-Ibuprofen and Mefloquine-Ketoprofen Systems. A Structural and Thermochemical Analysis.Chirality · 2026Article
212 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
About more than half of the drugs currently in use are chiral compounds and near 90% of the last ones are marketed as racemates consisting of an equimolar mixture of two enantiomers. Although they have the same chemical structure, most isomers of chiral drugs exhibit marked differences in biological activities such as pharmacology, toxicology, pharmacokinetics, metabolism etc. Some mechanisms of these properties are also explained. Therefore, it is important to promote the chiral separation and analysis of racemic drugs in pharmaceutical industry as well as in clinic in order to eliminate the unwanted isomer from the preparation and to find an optimal treatment and a right therapeutic control for the patient. In this article, we review the nomenclature, pharmacology, toxicology, pharmacokinetics, metabolism etc of some usual chiral drugs as well as their mechanisms. Different techniques used for the chiral separation in pharmaceutical industry as well as in clinical analyses are also examined.
Indexed as
Identifiers
23674971PMC3614593What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.