ReviewAdvances in nutrition (Bethesda, Md.)2013
Dietary fats and health: dietary recommendations in the context of scientific evidence.
Review in Advances in nutrition (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 174 citations in OpenAlex.
- Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies.PLoS medicine · 2018Pooled it
- Dietary Fat Intake and Risk of Gastric Cancer: A Meta-Analysis of Observational Studies.PloS one · 2015Pooled it
- Trial
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- Impact of olive oil and different animal fats on tissue lipid profiles of C57PL/6N mice fed non-atherogenic diet.Scientific reports · 2025Article
- Investigation of the Effects of Polyunsaturated Fatty Acid Ratios in Human SH-SY5Y Cells byTurkish journal of pharmaceutical sciences · 2025Article
- Red Meat Amino Acids for Beginners: A Narrative Review.Nutrients · 2025Review
- Cognition of diet quality and dietary management in elderly patients with coronary and other atherosclerotic vascular disease in western China, a qualitative research study.BMC geriatrics · 2024Article
- The impact of the Mediterranean diet on immune function in older adults.Aging clinical and experimental research · 2024Review
- Changes in Body Composition and Nutritional Periodization during the Training Macrocycle in Football-A Narrative Review.Nutrients · 2024Review
- Impact of serum eicosapentaenoic acid/arachidonic acid ratio on overall survival in lung cancer patients treated with pembrolizumab: a pilot study.Scientific reports · 2024Article
- Feeding regimens affecting carcass and quality attributes of sheep and goat meat - A comprehensive review.Animal bioscience · 2023Article
- Review
- Plant-Based Alternative Products: Are They Healthy Alternatives? Micro- and Macronutrients and Nutritional Scoring.Nutrients · 2022Article
- Fatty Acid Composition of Grain- and Grass-Fed Beef and Their Nutritional Value and Health Implication.Food science of animal resources · 2022Review
- The impact of moderate endurance exercise on cardiac telomeres and cardiovascular remodeling in obese rats.Frontiers in cardiovascular medicine · 2022Article
- The Role of Diet and Gut Microbiota in Regulating Gastrointestinal and Inflammatory Disease.Frontiers in immunology · 2022Review
- Do adults and older people follow current guidelines for milk consumption?Public health nutrition · 2021Article
- Perspective: The Saturated Fat-Unsaturated Oil Dilemma: Relations of Dietary Fatty Acids and Serum Cholesterol, Atherosclerosis, Inflammation, Cancer, and All-Cause Mortality.Advances in nutrition (Bethesda, Md.) · 2021Article
- Implementation of a Low-Carbohydrate Diet Improves the Quality of Life of Cancer Patients - An Online Survey.Frontiers in nutrition · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although early studies showed that saturated fat diets with very low levels of PUFAs increase serum cholesterol, whereas other studies showed high serum cholesterol increased the risk of coronary artery disease (CAD), the evidence of dietary saturated fats increasing CAD or causing premature death was weak. Over the years, data revealed that dietary saturated fatty acids (SFAs) are not associated with CAD and other adverse health effects or at worst are weakly associated in some analyses when other contributing factors may be overlooked. Several recent analyses indicate that SFAs, particularly in dairy products and coconut oil, can improve health. The evidence of ω6 polyunsaturated fatty acids (PUFAs) promoting inflammation and augmenting many diseases continues to grow, whereas ω3 PUFAs seem to counter these adverse effects. The replacement of saturated fats in the diet with carbohydrates, especially sugars, has resulted in increased obesity and its associated health complications. Well-established mechanisms have been proposed for the adverse health effects of some alternative or replacement nutrients, such as simple carbohydrates and PUFAs. The focus on dietary manipulation of serum cholesterol may be moot in view of numerous other factors that increase the risk of heart disease. The adverse health effects that have been associated with saturated fats in the past are most likely due to factors other than SFAs, which are discussed here. This review calls for a rational reevaluation of existing dietary recommendations that focus on minimizing dietary SFAs, for which mechanisms for adverse health effects are lacking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.