ReviewAdvances in nutrition (Bethesda, Md.)2013
Nutritional interventions to alleviate the negative consequences of heat stress.
Review in Advances in nutrition (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 244 citations in OpenAlex.
- Effects of Indoor Thermal Environment on Human Food Intake, Productivity, and Comfort: Pilot, Randomized, Crossover Trial.Obesity (Silver Spring, Md.) · 2018Trial
- Trial
- Extrusion of whole cottonseed enhances nutrient utilization, rumen fermentation, and circulating metabolites and amino acid profiles in heat-stressed lactating Holstein cows.Veterinary and animal science · 2026Article
- High ambient temperature activates a neural circuit for gut glucose uptake in male mice.Nature communications · 2026Article
- Ovarian Function, Hormonal, Metabolic, Oxidative Stress, and Gene Expression Biomarker Responses of Holstein Heifers Under Heat Stress Conditions to a Reduced Dose of Nanofabricated GnRH Analog Within the Ovsynch Protocol.Animals : an open access journal from MDPI · 2026Article
- Nutritional Strategies to Mitigate Heat Stress in Cattle: A Narrative Review.Microorganisms · 2026Review
- Exploring the adaptive responses to acute heat stress in crossbred calves of Kerala under controlled climatic conditions.Tropical animal health and production · 2026Article
- Consequences of Heat Stress on Physiology, Microbiome Dynamics, and Multi-Omics in Dairy Cows: More than Meets the Eye.Biology · 2026Review
- Characterization of novel lncRNA adrenal expression profiles in response to heat stress in rats.Functional & integrative genomics · 2026Article
- Heat Shock Affects Amino Acid Metabolism in Bovine Cumulus Cells and Denuded Oocytes During In Vitro Maturation.Biology · 2026Article
- Nanozymes or Spirulina Platensis: Enhancing Sheep Thermo-Tolerance Through Physio-Metabolic, Immune, and Antioxidant Pathways.Biological trace element research · 2025Article
- Gut microbial contributions to thermogenesis.The Journal of experimental biology · 2025Review
- Comparative transcriptomic analysis reveals the important role of hepatic fatty acid metabolism in the acute heat stress response in chickens.BMC genomics · 2025Article
- Rumination Time, Reticulorumen Temperature, and Activity in Relation to Postpartum Health Status in Dairy Cows During Heat Stress.Animals : an open access journal from MDPI · 2025Article
- Environment-Associated Variations in Blood Metabolism of Mongolian Cattle Grazing in the Alxa Desert of China.Veterinary sciences · 2025Article
- Edaravone's reno-protective effects against chronic heat-stress exposure.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Effect of heat stress on pig production and its mitigation strategies: a review.Tropical animal health and production · 2025Review
- Role of micronutrients in production and reproduction of farm animals under climate change scenario.Tropical animal health and production · 2025Review
- Stress and Strain: Differentiating the Responses to High and Moderate Heat Loads and Subsequent Recovery in Grain-Fed Feedlot Steers-Metabolic Hormones.Animals : an open access journal from MDPI · 2025Article
- Dietary encapsulated essential oils improve growth performance and regulate stress-responsive genes in heat-stressed broilers.Journal of animal science · 2025Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Energy metabolism is a highly coordinated process, and preferred fuel(s) differ among tissues. The hierarchy of substrate use can be affected by physiological status and environmental factors including high ambient temperature. Unabated heat eventually overwhelms homeothermic mechanisms resulting in heat stress, which compromises animal health, farm animal production, and human performance. Various aspects of heat stress physiology have been extensively studied, yet a clear understanding of the metabolic changes occurring at the cellular, tissue, and whole-body levels in response to an environmental heat load remains ill-defined. For reasons not yet clarified, circulating nonesterified fatty acid levels are reduced during heat stress, even in the presence of elevated stress hormones (epinephrine, glucagon, and cortisol), and heat-stressed animals often have a blunted lipolytic response to catabolic signals. Either directly because of or in coordination with this, animals experiencing environmental hyperthermia exhibit a shift toward carbohydrate use. These metabolic alterations occur coincident with increased circulating basal and stimulated plasma insulin concentrations. Limited data indicate that proper insulin action is necessary to effectively mount a response to heat stress and minimize heat-induced damage. Consistent with this idea, nutritional interventions targeting increased insulin action may improve tolerance and productivity during heat stress. Further research is warranted to uncover the effects of heat on parameters associated with energy metabolism so that more appropriate and effective treatment methodologies can be designed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.