ArticleHuman brain mapping2014
Functional MRI of cerebellar activity during eyeblink classical conditioning in children and adults.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed.
- Associative learning via eyeblink conditioning differs by age from infancy to adulthood.Communications psychology · 2024Article
- Neurite density of the hippocampus is associated with trace eyeblink conditioning latency in 4- to 6-year-olds.The European journal of neuroscience · 2024Article
- Disrupted executive cerebro-cerebellar functional connectivity in alcohol use disorder.Alcohol, clinical & experimental research · 2024Article
- Theta burst stimulation on the fronto-cerebellar connective network promotes cognitive processing speed in the simple cognitive task.Frontiers in human neuroscience · 2024Article
- Classical conditioning of faciliatory paired-pulse TMS.Scientific reports · 2023Article
- Human cerebellum and corticocerebellar connections involved in emotional memory enhancement.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Magnitude comparison and automaticity in number processing in adolescents with prenatal alcohol exposure: An event-related potentials study.Alcoholism, clinical and experimental research · 2022Article
- Role of cerebellar cortex in associative learning and memory in guinea pigs.Open life sciences · 2022Article
- Lesions causing hallucinations localize to one common brain network.Molecular psychiatry · 2021Article
- Cerebellar Activation Deficits in Schizophrenia During an Eyeblink Conditioning Task.Schizophrenia bulletin open · 2021Article
- Investigating cerebellar neural function in schizophrenia using delay eyeblink conditioning: A pilot fMRI study.Psychiatry research. Neuroimaging · 2020Article
- Neural Substrates Underlying Eyeblink Classical Conditioning in Adults With Alcohol Use Disorders.Alcoholism, clinical and experimental research · 2020Article
- Intracerebellar cannabinoid administration impairs delay but not trace eyeblink conditioning.Behavioural brain research · 2020Article
- Patterns of Cerebellar Connectivity with Intrinsic Connectivity Networks in Autism Spectrum Disorders.Journal of autism and developmental disorders · 2019Article
- The cerebellar cognitive affective/Schmahmann syndrome scale.Brain : a journal of neurology · 2018Article
- Cerebellar-dependent associative learning is impaired in very preterm born children and young adults.Scientific reports · 2017Article
- Functional MRI of Human Eyeblink Classical Conditioning in Children with Fetal Alcohol Spectrum Disorders.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Heavy Prenatal Alcohol Exposure is Related to Smaller Corpus Callosum in Newborn MRI Scans.Alcoholism, clinical and experimental research · 2017Article
- Altered Cerebellar Activity in Visceral Pain-Related Fear Conditioning in Irritable Bowel Syndrome.Cerebellum (London, England) · 2017Article
- Reinforcement Learning in Autism Spectrum Disorder.Frontiers in psychology · 2017Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
This study characterized human cerebellar activity during eyeblink classical conditioning (EBC) in children and adults using functional magnetic resonance imaging (fMRI). During fMRI, participants were administered delay conditioning trials, in which the conditioned stimulus (a tone) precedes, overlaps, and coterminates with the unconditioned stimulus (a corneal airpuff). Behavioral eyeblink responses and brain activation were measured concurrently during two phases: pseudoconditioning, involving presentations of tone alone and airpuff alone, and conditioning, during which the tone and airpuff were paired. Although all participants demonstrated significant conditioning, the adults produced more conditioned responses (CRs) than the children. When brain activations during pseudoconditioning were subtracted from those elicited during conditioning, significant activity was distributed throughout the cerebellar cortex (Crus I-II, lateral lobules IV-IX, and vermis IV-VI) in all participants, suggesting multiple sites of associative learning-related plasticity. Despite their less optimal behavioral performance, the children showed greater responding in the pons, lateral lobules VIII, IX, and Crus I, and vermis VI, suggesting that they may require greater activation and/or the recruitment of supplementary structures to achieve successful conditioning. Correlation analyses relating brain activations to behavioral CRs showed a positive association of activity in cerebellar deep nuclei (including dentate, fastigial, and interposed nuclei) and vermis VI with CRs in the children. This is the first study to compare cerebellar cortical and deep nuclei activations in children versus adults during EBC.
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Registered trials
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