ArticleBritish journal of cancer2013
TNF-receptor-1 adaptor protein FAN mediates TNF-induced B16 melanoma motility and invasion.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Development of a Macrophage-Related Risk Model for Metastatic Melanoma.International journal of molecular sciences · 2023Article
- Rethinking the chemokine cascade in brain metastasis: Preventive and therapeutic implications.Seminars in cancer biology · 2022Review
- Tumor microenvironment differences between primary tumor and brain metastases.Journal of translational medicine · 2020Review
- New variant identified in major susceptibility locus to tuberculosis on chromosomal region 8q12-q13 in Moroccan population: a case control study.BMC infectious diseases · 2017Article
- Brain metastasis: Unique challenges and open opportunities.Biochimica et biophysica acta. Reviews on cancer · 2017Review
- TNF-R1, an immune checkpoint in melanoma?Genes & cancer · 2015Article
- Intracellular Theileria annulata promote invasive cell motility through kinase regulation of the host actin cytoskeleton.PLoS pathogens · 2014Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
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Abstract
backgroundLocomotion of cancer cells can be induced by TNF and other motogenic factors secreted by cells of the tumour microenvironment such as macrophages. Based on our recent findings that the TNF receptor adaptor protein FAN mediates TNF-induced actin reorganisation and regulates the directed migration of immune cells responding to chemotactic cues, we addressed the role of FAN in cancer cell motility and the formation of invadopodia, a crucial feature in tumour invasion.
methodsIn B16 mouse melanoma cells, FAN was downregulated and the impact on FAN on cell motility and invasion was determined using in vitro assays and in vivo animal models.
resultsLike FAN(-/-) murine embryonic fibroblasts, FAN-deficient B16 melanoma cells showed defective motility responses to TNF in vitro. In vivo FAN-deficient B16 melanoma cells produced significantly less disseminated tumours after i.v. injection into mice. Danio rerio used as a second in vivo model also revealed impaired spreading of FAN-deficient B16 melanoma cells. Furthermore, FAN mediated TNF-induced paxillin phosphorylation, metalloproteinase activation and increased extracellular matrix degradation, the hallmarks of functionally active invadopodia.
conclusionThe results of our study suggest that FAN through promoting melanoma cellular motility and tumour invasiveness is critical for the tumour-promoting action of TNF.
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