ArticleGut microbes
Do gut microbial communities differ in pediatric IBS and health?
Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Fecal Microbial Composition and Predicted Functional Profile in Irritable Bowel Syndrome Differ between Subtypes and Geographical Locations.Microorganisms · 2023Article
- Gut Microbiome Remains Static in Functional Abdominal Pain Disorders Patients Compared to Controls: Potential for Diagnostic Tools.Biotech (Basel (Switzerland)) · 2022Article
- Article
- The Biogeography of Fungal Communities Across Different Chinese Wine-Producing Regions Associated With Environmental Factors and Spontaneous Fermentation Performance.Frontiers in microbiology · 2021Article
- A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota.Journal of sleep research · 2020Article
- Age-specific differential changes on gut microbiota composition in patients with major depressive disorder.Aging · 2020Article
- Characteristic dysbiosis of gut microbiota of Chinese patients with diarrhea-predominant irritable bowel syndrome by an insight into the pan-microbiome.Chinese medical journal · 2019Article
- Article
- Article
- Irritable bowel syndrome in children: Current knowledge, challenges and opportunities.World journal of gastroenterology · 2018Review
- The Management of Paediatric Functional Abdominal Pain Disorders: Latest Evidence.Paediatric drugs · 2018Review
- Advantages of phylogenetic distance based constrained ordination analyses for the examination of microbial communities.Scientific reports · 2017Article
- Epigenetic Matters: The Link between Early Nutrition, Microbiome, and Long-term Health Development.Frontiers in pediatrics · 2017Review
- The microbiome of the oral mucosa in irritable bowel syndrome.Gut microbes · 2016Article
- Application of multivariate statistical techniques in microbial ecology.Molecular ecology · 2016Review
- The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood.Clinical medicine insights. Pediatrics · 2016Review
- Simultaneous fecal microbial and metabolite profiling enables accurate classification of pediatric irritable bowel syndrome.Microbiome · 2015Article
- The networks of human gut microbe-metabolite associations are different between health and irritable bowel syndrome.The ISME journal · 2015Article
- Inference of Network Dynamics and Metabolic Interactions in the Gut Microbiome.PLoS computational biology · 2015Article
- Comparison of Fecal Microbiota in Children with Autism Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection.PloS one · 2015Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Human gastrointestinal microbial communities are recognized as important determinants of the host health and disease status. We have recently examined the distal gut microbiota of two groups of children: healthy adolescents and those diagnosed with diarrhea-predominant irritable bowel syndrome (IBS). We have revealed the common core of phylotypes shared among all children, identified genera differentially abundant between two groups and surveyed possible relationships among intestinal microbial genera and phylotypes. In this article we explored the use of supervised and unsupervised ordination and classification methods to separate and classify child fecal samples based on their quantitative microbial profile. We observed sample separation according to the participant health status, and this separation could often be attributed to the abundance levels of several specific microbial genera. We also extended our original correlation network analysis of the relative abundances of bacterial genera across samples and determined possible association networks separately for healthy and IBS groups. Interestingly, the number of significant genus abundance associations was drastically lower among the IBS samples, which can potentially be attributed to the existence of multiple routes to microbiota disbalance in IBS or to the loss of microbial interactions during IBS development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.