ArticleEnvironmental science and pollution research international2013
Cadmium in blood of Tunisian men and risk of bladder cancer: interactions with arsenic exposure and smoking.
Article in Environmental science and pollution research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Cancer risk in waterpipe smokers: a meta-analysis.International journal of public health · 2017Pooled it
- Relationships between blood cadmium concentration and risk of nine cancers: evidence from the NHANES 1999-2018 and Mendelian randomization analyses.Discover oncology · 2024Article
- Estimated Cancer Incidence in Northern Tunisia in 2023: Northern Tunisia Cancer Registry.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Does the Presence of Heavy Metals Influence the Gene Expression and Oxidative Stress in Bladder Cancer?Biological trace element research · 2024Article
- Uncovering the epidemiology of bladder cancer in the Arab world: A review of risk factors, molecular mechanisms, and clinical features.Asian journal of urology · 2024Review
- Unveiling an Association between Waterpipe Smoking and Bladder Cancer Risk: A Multicenter Case-Control Study in Iran.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- An exploratory study on the association of multiple metals in serum with preeclampsia.Frontiers in public health · 2024Article
- The role of autophagy in metal-induced urogenital carcinogenesis.Seminars in cancer biology · 2021Review
- Erythrocytes as a Model for Heavy Metal-Related Vascular Dysfunction: The Protective Effect of Dietary Components.International journal of molecular sciences · 2021Review
- Correlation between blood levels of cadmium and lead and the expression of microRNA-21 in Egyptian bladder cancer patients.Heliyon · 2020Article
- lncRNA OTUD6B-AS1 Exacerbates AsOxidative medicine and cellular longevity · 2020Article
- New insights on occupational exposure and bladder cancer risk: a pooled analysis of two Italian case-control studies.International archives of occupational and environmental health · 2019Article
- Specificity of the Metallothionein-1 Response by Cadmium-Exposed Normal Human Urothelial Cells.International journal of molecular sciences · 2019Article
- Environmental Health Research in Africa: Important Progress and Promising Opportunities.Frontiers in genetics · 2019Review
- Response of soil microbial communities to red mud-based stabilizer remediation of cadmium-contaminated farmland.Environmental science and pollution research international · 2018Article
- Risk assessment of occupational exposure to heavy metal mixtures: a study protocol.BMC public health · 2018Article
- Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population.Environmental science and pollution research international · 2017Article
- Genotoxic effects of cadmium in human head and neck cell line SQ20B.Environmental science and pollution research international · 2016Article
- A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment.Environmental science and pollution research international · 2016Review
- Association between blood arsenic levels and nasal polyposis disease risk in the Tunisian population.Environmental science and pollution research international · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prior investigations identified an association between low-level blood arsenic (As) and bladder cancer risk among Tunisian men but questions remain regarding confounding by cadmium (Cd), a well-established bladder carcinogen. A case-control study of Tunisian men was re-examined to assess the levels of cadmium in blood and reparse the association between the simultaneous exposure to these metals and bladder cancer risk. Levels of blood Cd were significantly twice higher among cases than in controls (P<0.05) and were positively correlated with smoking and age. Additionally, analysis of metal levels among non-smokers according to the region of residence showed very high blood Cd and As levels for the coastal regions of Sfax and central Tunisia. After controlling for potential confounders, for low blood As levels (<0.67 μg/L), the OR for blood Cd was 4.10 (95 % CI 1.64-10.81), while for higher levels (>0.67 μg/L), it was reduced to 2.10 (CI, 1.06-4.17). Adjustment for Cd exposure did not alter the risk associated to As exposure. This study is the first to report the relationship between Cd exposure and risk of bladder cancer occurrence in interaction with smoking and As exposure. Smoking is shown to be the main exposure source to Cd in the Tunisian population but also environmental pollution seems to be responsible of Cd exposure among non-smokers. Exposure assessment studies encompassing a wider population are needed.
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