ArticleSleep & breathing = Schlaf & Atmung2014
The impact of obesity on cardiac dysfunction in patients with sleep-disordered breathing.
Article in Sleep & breathing = Schlaf & Atmung, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- The Prevalence and Characteristics of Obstructive Sleep Apnea Among Patients With Multiple Sclerosis: A Systematic Review and Meta-Analysis.Journal of central nervous system disease · 2026Article
- Longitudinal effect of nocturnal R-R intervals changes on cardiovascular outcome in a community-based cohort.BMJ open · 2019Article
- Increased ultrasensitive C-reactive protein is not associated with obesity in hospitalized heart failure patients.Einstein (Sao Paulo, Brazil)Article
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Authors and funding
3 authors at 3 institutions in 1 country.
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Abstract
introductionObesity and heart failure are strongly associated with sleep-disordered breathing (SDB). However, the determinants of cardiac dysfunction in patients with SDB are not known.
methodsWe studied 90 patients suspected of having SDB (66 % women and 67 % black), age 50.4 ± 13.4 years and body mass index (BMI) 38.6 ± 9.8 kg/m(2). Apnea-hypopnea index (AHI) and nadir pulse oximetry (SpO2) were determined by polysomnography recordings. Left atrial (LA) diameter and left ventricular posterior wall (LVPW) thickness were determined by echocardiography. Patients who had EF<50 %, estimated right ventricular systolic pressure >45 mmHg or valvular heart disease were excluded.
resultsUnivariate analysis revealed a positive correlation between LA diameter and each of BMI, neck circumference (NC), and AHI (coefficients, 0.28, 0.34, and 0.36, respectively; p<0.05). Multivariable linear regression analysis revealed that BMI was the only independent predictor of LA enlargement (coefficient 0.02, p<0.05). LVPW thickness correlated with BMI, NC, and AHI (correlation coefficients were 0.43, 0.47, and 0.33, respectively; p<0.05). Multivariable linear regression analysis revealed a significant relationship between LVPW thickness and each of BMI and NC (coefficients 0.016 and 0.007, respectively; p<0.05) but not AHI. BMI and LVPW associated with nadir SpO2 (r=-0.60, p<0.01 and r=-0.21, p=0.05; respectively), and BMI was a predictor of nadir SpO2 during sleep (B=-0.59; CI: -0.84, -0.33; p=0.01).
conclusionsObesity can predict cardiovascular morbidity and nocturnal hypoxemia independent of the severity of the SDB. Our findings suggest the independent contribution of excess body weight on cardiac dysfunction and hypoxia in SDB patients.
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