ReviewChemical communications (Cambridge, England)2013
11CO2 fixation: a renaissance in PET radiochemistry.
Review in Chemical communications (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade.International journal of molecular sciences · 2022Pooled it
- Reliable One-Pot Automated Preparation of [Journal of labelled compounds & radiopharmaceuticals · 2026Article
- Carbon-11 Production: Communication, Operations, Maintenance, Troubleshooting, and Analysis for Maintaining High-Grade Bombardment and Provisions of [Molecules (Basel, Switzerland) · 2026Article
- Development and Optimization ofACS pharmacology & translational science · 2023Review
- Core-Labeling (Radio) Synthesis of Phenols.Organic letters · 2023Article
- Radiochemistry for positron emission tomography.Nature communications · 2023Review
- Recent Developments in Carbon-11 Chemistry and Applications for First-In-Human PET Studies.Molecules (Basel, Switzerland) · 2023Review
- Ring-opening of non-activated aziridines with [RSC advances · 2022Article
- Automated light-induced synthesis ofScientific reports · 2022Article
- Silicon compounds in carbon-11 radiochemistry: present use and future perspectives.Organic & biomolecular chemistry · 2021Article
- Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development.Journal of medicinal chemistry · 2021Review
- Radiosynthesis of [Frontiers in nuclear medicine · 2021Article
- Fully Automated Radiosynthesis of [ACS medicinal chemistry letters · 2020Article
- Rapid one-pot radiosynthesis of [carbonyl-EJNMMI radiopharmacy and chemistry · 2020Article
- Rapid and Efficient Synthesis of [ACS omega · 2020Article
- Transition-Metal-Free Carbon Isotope Exchange of Phenyl Acetic Acids.Angewandte Chemie (International ed. in English) · 2020Article
- Formal C-H Carboxylation of Unactivated Arenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Synthesis and pharmacokinetic study of aBioorganic & medicinal chemistry letters · 2020Article
- Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [Chemical communications (Cambridge, England) · 2020Article
- Copper(I)-MediatedACS omega · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Carbon-11 labelled carbon dioxide is the cyclotron-generated feedstock reagent for most positron emission tomography (PET) tracers using this radionuclide. Most carbon-11 labels, however, are installed using derivative reagents generated from [(11)C]CO2. In recent years, [(11)C]CO2 has seen a revival in applications for the direct incorporation of carbon-11 into functional groups such as ureas, carbamates, oxazolidinones, carboxylic acids, esters, and amides. This review summarizes classical [(11)C]CO2 fixation strategies using organometallic reagents and then focuses on newly developed methods that employ strong organic bases to reversibly capture [(11)C]CO2 into solution, thereby enabling highly functionalized labelled compounds to be prepared. Labelled compounds and radiopharmaceuticals that have been translated to the clinic are highlighted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.