ArticleNature communications2013
Calfacilitin is a calcium channel modulator essential for initiation of neural plate development.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Calcium signaling is required for anterior patterning in the mouse embryo.PLoS biology · 2025Article
- Deciphering the Calcium Code: A Review of Calcium Activity Analysis Methods Employed to Identify Meaningful Activity in Early Neural Development.Biomolecules · 2024Review
- MicroRNAs Regulate CaCells · 2023Article
- A gene regulatory network for neural induction.eLife · 2023Article
- Exploring the roles of FGF/MAPK and cVG1/GDF signalling on mesendoderm induction and convergent extension during chick primitive streak formation.Development genes and evolution · 2022Article
- 'Neighbourhood watch' model: embryonic epiblast cells assess positional information in relation to their neighbours.Development (Cambridge, England) · 2022Article
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- Article
- Trpc1 as the Missing Link Between the Bmp and CaScientific reports · 2019Article
- Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids.Journal of virology · 2019Article
- Membrane fluidity is regulated by theeLife · 2018Article
- Neural differentiation, selection and transcriptomic profiling of human neuromesodermal progenitor-like cellsDevelopment (Cambridge, England) · 2018Article
- Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Calreticulin is a secreted BMP antagonist, expressed in Hensen's node during neural induction.Developmental biology · 2017Article
- PROS-1/Prospero Is a Major Regulator of the Glia-Specific Secretome Controlling Sensory-Neuron Shape and Function in C. elegans.Cell reports · 2016Article
- Regulation of neurogenesis by calcium signaling.Cell calcium · 2016Review
- Retinoic acid signaling and neuronal differentiation.Cellular and molecular life sciences : CMLS · 2015Review
- The role of voltage-gated calcium channels in neurotransmitter phenotype specification: Coexpression and functional analysis in Xenopus laevis.The Journal of comparative neurology · 2014Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Calcium fluxes have been implicated in the specification of the vertebrate embryonic nervous system for some time, but how these fluxes are regulated and how they relate to the rest of the neural induction cascade is unknown. Here we describe Calfacilitin, a transmembrane calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type CaV1.2 channel. Calfacilitin binds to this channel and is co-expressed with it in the embryo. Regulation of intracellular calcium by Calfacilitin is required for expression of the neural plate specifiers Geminin and Sox2 and for neural plate formation. Loss-of-function of Calfacilitin can be rescued by ionomycin, which increases intracellular calcium. Our results elucidate the role of calcium fluxes in early neural development and uncover a new factor in the modulation of calcium signalling.
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