ArticleJournal of structural and functional genomics2013
Crystal structure of AcrB complexed with linezolid at 3.5 Å resolution.
Article in Journal of structural and functional genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Structural insights into a substrate translocation pathway revealed by the RND efflux pump complex MexJK fromScience advances · 2026Article
- Assembly and inhibition of transferable TMexCD1-TOprJ1 efflux pump.Nature communications · 2025Article
- Article
- The culmination of multidrug-resistant efflux pumps vs. meager antibiotic arsenal era: Urgent need for an improved new generation of EPIs.Frontiers in microbiology · 2023Review
- Review
- Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae.Nature communications · 2021Article
- Structural Insights into Transporter-Mediated Drug Resistance in Infectious Diseases.Journal of molecular biology · 2021Review
- Structural and Functional Diversity of Resistance-Nodulation-Cell Division Transporters.Chemical reviews · 2021Review
- Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.Chemical reviews · 2021Review
- Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter fromMicroorganisms · 2020Article
- Article
- Crystal structures of multidrug efflux pump MexB bound with high-molecular-mass compounds.Scientific reports · 2019Article
- Multidrug efflux pumps: structure, function and regulation.Nature reviews. Microbiology · 2018Review
- Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB.Nature communications · 2016Article
- Evidence of a Substrate-Discriminating Entrance Channel in the Lower Porter Domain of the Multidrug Resistance Efflux Pump AcrB.Antimicrobial agents and chemotherapy · 2016Article
- Effective in silico prediction of new oxazolidinone antibiotics: force field simulations of the antibiotic-ribosome complex supervised by experiment and electronic structure methods.Beilstein journal of organic chemistry · 2016Article
- The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.Clinical microbiology reviews · 2015Review
- Structural basis of RND-type multidrug exporters.Frontiers in microbiology · 2015Review
- Recent advances toward a molecular mechanism of efflux pump inhibition.Frontiers in microbiology · 2015Review
- Molecular mechanisms of antibiotic resistance.Nature reviews. Microbiology · 2015Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
AcrB is an inner membrane resistance-nodulation-cell division efflux pump and is part of the AcrAB-TolC tripartite efflux system. We have determined the crystal structure of AcrB with bound Linezolid at a resolution of 3.5 Å. The structure shows that Linezolid binds to the A385/F386 loops of the symmetric trimer of AcrB. A conformational change of a loop in the bottom of the periplasmic cleft is also observed.
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