ArticleScientific reports2013
Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04830969 (Impact of Periodontal Therapy on Patients With Diabetes), which is not on this map. Cited by 132 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Periodontal Therapy on Patients With Diabetes: A Pilot Study
Who cites it
132 citing papers in PubMed, 3 syntheses or guidelines pooled it, 242 citations in OpenAlex.
- Pooled it
- Definitions used for a healthy periodontium-A systematic review.International journal of dental hygiene · 2020Pooled it
- Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis.Scientific reports · 2015Pooled it
- Probiotics Augment the Effect of Non-Surgical Periodontal Treatment-A Randomised, Double-Blinded, Placebo-Controlled Trial.Journal of clinical periodontology · 2026Trial
- Variations in oral microbiota associated with oral cancer.Scientific reports · 2017Trial
- Soil-plant-animal properties and microbial reassembly distinguish cattle oral disease prevalence across converted Amazon pasture systems.Environmental geochemistry and health · 2026Article
- The Role of the Oral Microbiome in the Development and Treatment of Periodontal Disease: Functional Meta-Omics Evidence.Current microbiology · 2026Review
- Metagenomics in the Interplay Among Oral and Gut Dysbiosis.Metabolites · 2026Review
- Exploring the oral microbiome: from traditional techniques to advanced omics and databases.Antonie van Leeuwenhoek · 2026Review
- Exploring the Therapeutic Potential of Diverse Bacterial Strains for Management of Periodontal Diseases.Probiotics and antimicrobial proteins · 2026Review
- Metagenomic insights into oral microbiota dynamics in diabetic and non-diabetic periodontal disease: a pilot study.Frontiers in microbiology · 2026Article
- Metagenome-based virome analysis identifies the oral viral signatures for periodontitis.Journal of oral microbiology · 2026Article
- Pathogenic oral microbiota abundance is associated with reduced bite force in patients with periodontitis.Journal of dental sciences · 2026Article
- The Role of Inflammasomes in Chronic Oral Inflammatory Disease and Oral Cancer: A Narrative Review.Dentistry journal · 2025Review
- Profiling the Bacterial Microbiome Across Peri-Implant Conditions.Journal of clinical periodontology · 2025Article
- Assessing the Oral Microbiome in Women of Reproductive Age: A Narrative Review.Clinics and practice · 2025Review
- The role of genome-wide DNA methylation and polymorphisms in periodontitis etiology: A narrative review.Biomolecules & biomedicine · 2025Review
- A Potential Link Between Oral Microbiota and Female Reproductive Health.Microorganisms · 2025Review
- Salivary microbiota dysbiosis and elevated polyamine levels contribute to the severity of periodontal disease.BMC oral health · 2025Article
- Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic.Frontiers in cellular and infection microbiology · 2025Review
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although attempts have been made to reveal the relationships between bacteria and human health, little is known about the species and function of the microbial community associated with oral diseases. In this study, we report the sequencing of 16 metagenomic samples collected from dental swabs and plaques representing four periodontal states. Insights into the microbial community structure and the metabolic variation associated with periodontal health and disease were obtained. We observed a strong correlation between community structure and disease status, and described a core disease-associated community. A number of functional genes and metabolic pathways including bacterial chemotaxis and glycan biosynthesis were over-represented in the microbiomes of periodontal disease. A significant amount of novel species and genes were identified in the metagenomic assemblies. Our study enriches the understanding of the oral microbiome and sheds light on the contribution of microorganisms to the formation and succession of dental plaques and oral diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.