ArticleAmerican journal of epidemiology2013
Anthropometric measures and the risk of endometrial cancer, overall and by tumor microsatellite status and histological subtype.
Article in American journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of endometrial cancer risk with hypertension- an updated meta-analysis of observational studies.Scientific reports · 2024Pooled it
- Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Pooled it
- Long-term association of physical activity with survival by primary cancer treatment in endometrial cancer: The Alberta Endometrial Cancer Cohort Study.International journal of cancer · 2026Article
- Observational
- Prospective cohort of pre-diagnosis hormone exposure and post-diagnosis sex hormone levels with survival outcomes: Alberta Endometrial Cancer Cohort Study.Endocrine oncology (Bristol, England) · 2025Article
- 17β-estradiol Inhibits Oxidative Stress-Induced Apoptosis in Endometrial Cancer Cells by Promoting FOXM1 Expression.Cell biochemistry and biophysics · 2024Article
- Clear cell endometrial carcinoma with high microsatellite instability in a complicated pregnancy: a case report.Journal of medical case reports · 2023Article
- Risk factors for endometrial cancer in Black women.Cancer causes & control : CCC · 2023Article
- Prospective Cohort of Pre- and Post-Diagnosis Diet with Survival Outcomes: an Alberta Endometrial Cancer Cohort Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- An effective algorithm to detect the possibility of being MSI phenotype in endometrial cancer given the BMI status and histological subtype: a statistical study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022Article
- Associations of insulin resistance and inflammatory biomarkers with endometrial cancer survival: The Alberta endometrial cancer cohort study.Cancer medicine · 2022Article
- Prospective Cohort Study of Pre- and Postdiagnosis Obesity and Endometrial Cancer Survival.Journal of the National Cancer Institute · 2022Article
- A review of menopause nomenclature.Reproductive health · 2022Review
- Visceral obesity and incident cancer and cardiovascular disease: An integrative review of the epidemiological evidence.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Review
- Prospective Cohort Study of Pre- and Postdiagnosis Physical Activity and Endometrial Cancer Survival.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020Article
- Excess Body Weight and Incidence of Type 1 and Type 2 Endometrial Cancer: The Norwegian Women and Cancer Study.Clinical epidemiology · 2020Article
- Endometrial cancer risk and survival by tumor MMR status.Journal of gynecologic oncology · 2018Article
- Body Size, Metabolic Factors, and Risk of Endometrial Cancer in Black Women.American journal of epidemiology · 2016Article
- Ethnic and geographic variations in corpus uteri cancer burden: evidence based on data from 29 states and the District of Columbia. CI5 IX, X and SEER data (1998-2010).Cancer causes & control : CCC · 2014Article
- Endometrial cancer and a family history of cancer.Gynecologic oncology · 2013Article
Corrections and comments
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Authors and funding
9 authors.
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Abstract
Obesity is an established risk factor for endometrial cancer, but this association is not well understood for subtypes of endometrial cancer. We evaluated the association of recent and adult-life obesity with subtypes of endometrial cancer based on microsatellite status (microsatellite-stable (MSS) vs. microsatellite-instable (MSI)) and histology (type I vs. type II). Analyses were based on a population-based case-control study (524 cases and 1,032 controls) conducted in Alberta, Canada (2002-2006) and included the following groupings of subtypes: MSS = 337 and MSI = 130; type I = 458 and type II = 66. Logistic and polytomous logistic regression were used to estimate odds ratios and 95% confidence intervals for overall endometrial cancer and subtypes of endometrial cancer, respectively. The risks of all subtypes of endometrial cancer, except type II, increased with an increase in all of the anthropometric characteristics examined. The risks for MSI tumors were suggestively stronger than those for MSS tumors; the risk with high (≥30) body mass index (weight (kg)/height (m)(2)) was significantly stronger for MSI tumors (odds ratio = 4.96, 95% confidence interval: 2.76, 8.91) than for MSS tumors (odds ratio = 2.33, 95% confidence interval: 1.66, 3.28) (P-heterogeneity = 0.02). Obesity is associated with most subtypes of endometrial cancer, and further studies are warranted to elucidate the biological mechanisms underlying the stronger risk for the MSI subtype with a high body mass index.
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