ReviewCritical care (London, England)2013
Clinical review: Acute respiratory distress syndrome - clinical ventilator management and adjunct therapy.
Review in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recruitment manoeuvres for adults with acute respiratory distress syndrome receiving mechanical ventilation: a systematic review and meta-analysis.Journal of critical care · 2019Pooled it
- Artificial intelligence and machine learning in acute respiratory distress syndrome management: recent advances.Frontiers in medicine · 2025Review
- Article
- Awake extracorporeal membrane oxygenation support for a critically ill COVID-19 patient: A case report.World journal of clinical cases · 2021Article
- Andrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice.Journal of pharmacological sciences · 2020Article
- Is the prone position indicated in critically ill patients with SARS-CoV-2 during the peri-operative period?Trends in anaesthesia & critical care · 2020Review
- Defining a Regulatory Strategy for ATMP/Aerosol Delivery Device Combinations in the Treatment of Respiratory Disease.Pharmaceutics · 2020Review
- The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation.Molecular medicine (Cambridge, Mass.) · 2020Article
- Mesenchymal stem cells combined with liraglutide relieve acute lung injury through apoptotic signaling restrained by PKA/β-catenin.Stem cell research & therapy · 2020Article
- Therapeutic use of mesenchymal stem cell-derived extracellular vesicles in acute lung injury.Transfusion · 2019Article
- Silymarin mitigates lung impairments in a rat model of acute respiratory distress syndrome.Inflammopharmacology · 2018Article
- The Basic Science and Molecular Mechanisms of Lung Injury and Acute Respiratory Distress Syndrome.International anesthesiology clinics · 2018Review
- Disseminated adenovirus infection causing severe ARDS.BMJ case reports · 2017Article
- Mesenchymal stem cell derived secretome and extracellular vesicles for acute lung injury and other inflammatory lung diseases.Expert opinion on biological therapy · 2016Review
- Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways.Acta pharmaceutica Sinica. B · 2016Article
- [Ventilation as a trigger for organ dysfunction and sepsis].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2016Review
- Erratum: Concordance and limits between transcutaneous and arterial carbon dioxide pressure in emergency department patients with acute respiratory failure: a single-center, prospective, and observational study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2015Article
- Effect of hypertonic saline treatment on the inflammatory response after hydrochloric acid-induced lung injury in pigs.Clinics (Sao Paulo, Brazil) · 2015Article
- Concordance and limits between transcutaneous and arterial carbon dioxide pressure in emergency department patients with acute respiratory failure: a single-center prospective observational study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2015Observational
- Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial.The Lancet. Respiratory medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute inflammatory lung injury with a high short-term mortality rate and significant long-term consequences among survivors. Supportive care, principally with mechanical ventilation, remains the cornerstone of therapy - although the goals of this support have changed in recent years - from maintaining normal physiological parameters to avoiding ventilator-induced lung injury while providing adequate gas exchange. In this article we discuss the current evidence base for ventilatory support and adjunctive therapies in patients with ARDS. Key components of such a strategy include avoiding lung overdistension by limiting tidal volumes and airway pressures, and the use of positive end-expiratory pressure with or without lung recruitment manoeuvres in patients with severe ARDS. Adjunctive therapies discussed include pharmacologic techniques (for example, vasodilators, diuretics, neuromuscular blockade) and nonpharmacologic techniques (for example, prone position, alternative modes of ventilation).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.