ReviewCritical care (London, England)2013
Clinical review: What are the best hemodynamic targets for noncardiac surgical patients?
Review in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Perioperative liberal versus restrictive fluid strategies and postoperative outcomes: a systematic review and metanalysis on randomised-controlled trials in major abdominal elective surgery.Critical care (London, England) · 2021Pooled it
- Association between perioperative fluid administration and postoperative outcomes: a 20-year systematic review and a meta-analysis of randomized goal-directed trials in major visceral/noncardiac surgery.Critical care (London, England) · 2021Pooled it
- Functional hemodynamic tests: a systematic review and a metanalysis on the reliability of the end-expiratory occlusion test and of the mini-fluid challenge in predicting fluid responsiveness.Critical care (London, England) · 2019Pooled it
- Pharmacodynamic analysis of a fluid challenge with 4 ml kgJournal of clinical monitoring and computing · 2022Trial
- A pragmatic multi-center trial of goal-directed fluid management based on pulse pressure variation monitoring during high-risk surgery.BMC anesthesiology · 2017Trial
- Impact of early haemodynamic goal-directed therapy in patients undergoing emergency surgery: an open prospective, randomised trial.Journal of clinical monitoring and computing · 2016Trial
- Peri-operative goal-directed haemodynamic therapy and high-risk patients: what's going on? A narrative review.Journal of anesthesia, analgesia and critical care · 2026Review
- Microcirculation dysfunction and cardioprotection in cardiac surgery with cardiopulmonary bypass: mechanisms, monitoring, and therapeutic strategies.Frontiers in cardiovascular medicine · 2026Review
- Tidal volume challenge-induced hemodynamic changes can predict fluid responsiveness during one-lung ventilation: an observational study.Frontiers in medicine · 2023Article
- Intraoperative haemodynamic optimisation therapy with venoarterial carbon dioxide difference and pulse pressure variation - does it work?Anaesthesiology intensive therapy · 2020Article
- Current concepts of perioperative monitoring in high-risk surgical patients: a review.Patient safety in surgery · 2019Review
- Goal-Directed Fluid Therapy on Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients.Obesity surgery · 2016Article
- Care of elderly patients: a prospective audit of the prevalence of hypotension and the use of BIS intraoperatively in 25 hospitals in London.Perioperative medicine (London, England) · 2016Article
- A web-based Italian survey of current trends, habits and beliefs in hemodynamic monitoring and management.Journal of clinical monitoring and computing · 2015Article
- Perioperative cardiovascular monitoring of high-risk patients: a consensus of 12.Critical care (London, England) · 2015Review
- New, goal-directed approach to renal replacement therapy improves acute kidney injury treatment after cardiac surgery.Journal of cardiothoracic surgery · 2014Observational
- Improving perioperative care in low-resource settings with goal-directed therapy: a narrative review.Brazilian journal of anesthesiology (Elsevier)Review
- [Perioperative central venous oxygen saturation and its correlation with mortality during cardiac surgery: an observational prospective study].Brazilian journal of anesthesiology (Elsevier)Observational
- What happens to the fluid balance during and after recovering from septic shock?Revista Brasileira de terapia intensivaObservational
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perioperative hemodynamic optimization, or goal-directed therapy (GDT), has been show to significantly decrease complications and risk of death in high-risk patients undergoing noncardiac surgery. An important aim of GDT is to prevent an imbalance between oxygen delivery and oxygen consumption in order to avoid the development of multiple organ dysfunction. The utilization of cardiac output monitoring in the perioperative period has been shown to improve outcomes if integrated into a GDT strategy. GDT guided by dynamic predictors of fluid responsiveness or functional hemodynamics with minimally invasive cardiac output monitoring is suitable for the majority of patients undergoing major surgery with expected significant volume shifts due to bleeding or other significant intravascular volume losses. For patients at higher risk of complications and death, such as those with advanced age and limited cardiorespiratory reserve, the addition of dobutamine or dopexamine to the treatment algorithm, to maximize oxygen delivery, is associated with better outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.