ArticleBMC medicine2013
Informing DSM-5: biological boundaries between bipolar I disorder, schizoaffective disorder, and schizophrenia.
Article in BMC medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Systematic Review of Functional MRI Applications for Psychiatric Disease Subtyping.Frontiers in psychiatry · 2021Pooled it
- Towards a brain-based predictome of mental illness.Human brain mapping · 2020Pooled it
- Exposure-Response Analysis for Aripiprazole Once-Monthly in Patients Diagnosed With Bipolar I Disorder.Clinical pharmacology in drug development · 2025Article
- The overlap across psychotic disorders: A functional network connectivity analysis.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024Article
- NeuroMark: An automated and adaptive ICA based pipeline to identify reproducible fMRI markers of brain disorders.NeuroImage. Clinical · 2020Article
- Using Two-Step Cluster Analysis and Latent Class Cluster Analysis to Classify the Cognitive Heterogeneity of Cross-Diagnostic Psychiatric Inpatients.Frontiers in psychology · 2020Article
- Identifying commonality and specificity across psychosis sub-groups via classification based on features from dynamic connectivity analysis.NeuroImage. Clinical · 2020Article
- Recent Genetics and Epigenetics Approaches to PTSD.Current psychiatry reports · 2018Review
- Classification and Prediction of Brain Disorders Using Functional Connectivity: Promising but Challenging.Frontiers in neuroscience · 2018Review
- Identifying dynamic functional connectivity biomarkers using GIG-ICA: Application to schizophrenia, schizoaffective disorder, and psychotic bipolar disorder.Human brain mapping · 2017Article
- Advances in Psychiatric Diagnosis: Past, Present, and Future.Behavioral sciences (Basel, Switzerland) · 2017Article
- Similar white matter changes in schizophrenia and bipolar disorder: A tract-based spatial statistics study.PloS one · 2017Article
- Changes in Painting Style by Poststroke Mania.Journal of stroke · 2016Article
- A critical appraisal of paliperidone long-acting injection in the treatment of schizoaffective disorder.Therapeutics and clinical risk management · 2016Review
- Article
- Longitudinal investigation of the relationship between family history of psychosis and affective disorders and Child Behavior Checklist ratings in clinical high-risk adolescents.Schizophrenia research · 2015Article
- What Have Mass Spectrometry-Based Proteomics and Metabolomics (Not) Taught Us about Psychiatric Disorders?Molecular neuropsychiatry · 2015Review
- Clinical predictors of therapeutic response to antipsychotics in schizophrenia.Dialogues in clinical neuroscience · 2014Review
- Problems in the boundaries of bipolar disorders.Current psychiatry reports · 2014Review
- Specificity of psychosis, mania and major depression in a contemporary family study.Molecular psychiatry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe fifth version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) opted to retain existing diagnostic boundaries between bipolar I disorder, schizoaffective disorder, and schizophrenia. The debate preceding this decision focused on understanding the biologic basis of these major mental illnesses. Evidence from genetics, neuroscience, and pharmacotherapeutics informed the DSM-5 development process. The following discussion will emphasize some of the key factors at the forefront of the debate. DISCUSSION: Family studies suggest a clear genetic link between bipolar I disorder, schizoaffective disorder, and schizophrenia. However, large-scale genome-wide association studies have not been successful in identifying susceptibility genes that make substantial etiological contributions. Boundaries between psychotic disorders are not further clarified by looking at brain morphology. The fact that symptoms of bipolar I disorder, but not schizophrenia, are often responsive to medications such as lithium and other anticonvulsants must be interpreted within a larger framework of biological research. SUMMARY: For DSM-5, existing nosological boundaries between bipolar I disorder and schizophrenia were retained and schizoaffective disorder preserved as an independent diagnosis since the biological data are not yet compelling enough to justify a move to a more neurodevelopmentally continuous model of psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.