ReviewJournal of cellular and molecular medicine2013
Mechanobiological dysregulation of the epidermis and dermis in skin disorders and in degeneration.
Review in Journal of cellular and molecular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 71 citations in OpenAlex.
- Construction and Application of a Tactile Somatosensory Comfort Model for Scrubbing Tasks.Biomimetics (Basel, Switzerland) · 2026Article
- Pressure and Skin: A Review of Disease Entities Driven or Influenced by Mechanical Pressure.American journal of clinical dermatology · 2024Review
- Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration.Nano-micro letters · 2024Review
- Back to the future: targeting the extracellular matrix to treat systemic sclerosis.Nature reviews. Rheumatology · 2023Review
- 3D-Printed Auxetic Skin Scaffold for Decreasing Burn Wound Contractures at Joints.Journal of functional biomaterials · 2023Article
- Close orthopedic surgery skin incision with combination of barbed sutures and running subcuticular suturing technique for less dermal tension concentration: a finite element analysis.Journal of orthopaedic surgery and research · 2023Article
- Using Zhang's supertension-relieving suture technique with slowly-absorbable barbed sutures in the management of pathological scars: a multicenter retrospective study.Burns & trauma · 2023Article
- S100 calcium-binding protein A9 promotes skin regeneration through toll-like receptor 4 during tissue expansion.Burns & trauma · 2023Article
- Mechanotransduction in Skin Inflammation.Cells · 2022Review
- Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin.Nature communications · 2022Article
- Comprehensive Analysis of Circular RNA Expression in ceRNA Networks and Identification of the Effects of hsa_circ_0006867 in Keloid Dermal Fibroblasts.Frontiers in molecular biosciences · 2022Article
- Mechanical and Immunological Regulation in Wound Healing and Skin Reconstruction.International journal of molecular sciences · 2021Review
- Mechanobiological Principles Influence the Immune Response in Regeneration: Implications for Bone Healing.Frontiers in bioengineering and biotechnology · 2021Review
- Mechanotransduction in Wound Healing and Fibrosis.Journal of clinical medicine · 2020Review
- A modified scar model with controlled tension on secondary wound healing in mice.Burns & trauma · 2020Article
- Immunohistochemical characterization of the M4 macrophage population in leprosy skin lesions.BMC infectious diseases · 2018Article
- Leprosy As a Complex Infection: Breakdown of the Th1 and Th2 Immune Paradigm in the Immunopathogenesis of the Disease.Frontiers in immunology · 2017Review
- Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin.The Journal of investigative dermatology · 2016Article
- Does severity of dermatochalasis in aging affect corneal biomechanical properties?Clinical interventions in aging · 2016Article
- An updated review of mechanotransduction in skin disorders: transcriptional regulators, ion channels, and microRNAs.Cellular and molecular life sciences : CMLS · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During growth and development, the skin expands to cover the growing skeleton and soft tissues by constantly responding to the intrinsic forces of underlying skeletal growth as well as to the extrinsic mechanical forces from body movements and external supports. Mechanical forces can be perceived by two types of skin receptors: (1) cellular mechanoreceptors/mechanosensors, such as the cytoskeleton, cell adhesion molecules and mechanosensitive (MS) ion channels, and (2) sensory nerve fibres that produce the somatic sensation of mechanical force. Skin disorders in which there is an abnormality of collagen [e.g. Ehlers-Danlos syndrome (EDS)] or elastic (e.g. cutis laxa) fibres or a malfunction of cutaneous nerve fibres (e.g. neurofibroma, leprosy and diabetes mellitus) are also characterized to some extent by deficiencies in mechanobiological processes. Recent studies have shown that mechanotransduction is crucial for skin development, especially hemidesmosome maturation, which implies that the pathogenesis of skin disorders such as bullous pemphigoid is related to skin mechanobiology. Similarly, autoimmune diseases, including scleroderma and mixed connective tissue disease, and pathological scarring in the form of keloids and hypertrophic scars would seem to be clearly associated with the mechanobiological dysfunction of the skin. Finally, skin ageing can also be considered as a degenerative process associated with mechanobiological dysfunction. Clinically, a therapeutic strategy involving mechanoreceptors or MS nociceptor inhibition or acceleration together with a reduction or augmentation in the relevant mechanical forces is likely to be successful. The development of novel approaches such as these will allow the treatment of a broad range of cutaneous diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.