ArticleBrain injury2013
Variants of SLC6A4 in depression risk following severe TBI.
Article in Brain injury, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effectiveness of Pharmacotherapy for Depression after Adult Traumatic Brain Injury: an Umbrella Review.Neuropsychology review · 2023Pooled it
- Genetic Influences on Patient-Oriented Outcomes in Traumatic Brain Injury: A Living Systematic Review of Non-Apolipoprotein E Single-Nucleotide Polymorphisms.Journal of neurotrauma · 2021Pooled it
- The Effect of Antidepressants on Depression After Traumatic Brain Injury: A Meta-analysis.The Journal of head trauma rehabilitationPooled it
- Exploring Synaptic Pathways in Traumatic Brain Injury: A Cross-Phenotype Genomics Approach.Journal of neurotrauma · 2025Article
- Genetic drivers of cerebral blood flow dysfunction in TBI: a speculative synthesis.Nature reviews. Neurology · 2019Review
- Placebo Effects in Traumatic Brain Injury.Journal of neurotrauma · 2018Review
- The pharmacogenomics of severe traumatic brain injury.Pharmacogenomics · 2017Review
- Applying Systems Biology Methodology To Identify Genetic Factors Possibly Associated with Recovery after Traumatic Brain Injury.Journal of neurotrauma · 2017Article
- A narrative literature review of depression following traumatic brain injury: prevalence, impact, and management challenges.Psychology research and behavior management · 2017Review
- Catecholaminergic based therapies for functional recovery after TBI.Brain research · 2016Review
- Article
- A Rehabilomics framework for personalized and translational rehabilitation research and care for individuals with disabilities: Perspectives and considerations for spinal cord injury.The journal of spinal cord medicine · 2014Article
- Posttraumatic Brain Injury Cognitive Performance Is Moderated by Variation Within ANKK1 and DRD2 Genes.The Journal of head trauma rehabilitationArticle
- Variation in the BDNF gene interacts with age to predict mortality in a prospective, longitudinal cohort with severe TBI.Neurorehabilitation and neural repairArticle
- Genetic Variation in the Vesicular Monoamine Transporter: Preliminary Associations With Cognitive Outcomes After Severe Traumatic Brain Injury.The Journal of head trauma rehabilitationArticle
- Effects of Depression and Antidepressant Use on Cognitive Deficits and Functional Cognition Following Severe Traumatic Brain Injury.The Journal of head trauma rehabilitationArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPost-traumatic depression (PTD) may be a result of several factors like secondary injury chemical cascades as well as psycho-social factors following traumatic brain injury (TBI). While the role of serotonin in the pathology and treatment of idiopathic major depression may be somewhat controversial, it is unclear what role serotonin may play in PTD following a TBI.
objectiveTo assess serotonergic function and genetic risk for PTD development over 1 year following TBI. RESEARCH
designExamination of variation in the serotonin transporter gene [SLC6A4 (5-HTTLPR, rs25331, and a variable number of tandem repeats variant in Intron 2)] in 109 subjects with moderate-severe injury. Depression was assessed using the Patient Health Questionnaire (PHQ-9) at 6 and/or 12 months post-injury. MAIN OUTCOMES AND
resultsAt 6 months post-injury, subjects with a history of pre-morbid mood disorders and 5-HTTLPR L-homozygotes were at greater risk for PTD. Contrary to major depression, subjects without pre-morbid mood disorders (n = 80) and S-carriers were 2.803-times less likely to be depressed compared to L-homozygotes. At 12 months post-injury, LG-carriers were also less likely to experience PTD. Temporal analysis also showed 5-HTTLPR associations in PTD development across recovery.
conclusionsThis study suggests a unique injury- and temporally-specific interaction between TBI and genetic risk for depression.
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