ArticleThe aging male : the official journal of the International Society for the Study of the Aging Male2013
Association of serum calcium with serum sex steroid hormones in men in NHANES III.
Article in The aging male : the official journal of the International Society for the Study of the Aging Male, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 9 citations in OpenAlex.
- Association between dietary calcium intake and benign prostatic hyperplasia: a population-based result from NHANES 2003 to 2008.Translational andrology and urology · 2025Article
- Altering maternal calcium and phosphorus dietary intake induces persistent sex-specific changes in the dentition of the offspring.Orthodontics & craniofacial research · 2024Article
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundBone is a positive regulator of male fertility, which indicates a link between regulation of bone remodeling and reproduction or more specifically a link between calcium and androgens. This possibly suggests how calcium is linked to prostate cancer development through its link with the reproductive system. We studied serum calcium and sex steroid hormones in the Third National Health and Nutrition Examination Survey (NHANES III).
methodsSerum calcium and sex steroid hormones were measured for 1262 men in NHANES III. We calculated multivariable-adjusted geometric means of serum concentrations of total and estimated free testosterone and estradiol, androstanediol glucuronide (AAG), and sex hormone binding globulin (SHBG) by categories of calcium (lowest 5% [<1.16 mmol/L], mid 90%, top 5% [≥1.30 mmol/L]).
resultsLevels of total and free testosterone, total estradiol or AAG did not differ across categories of serum calcium. Adjusted SHBG concentrations were 36.4 for the bottom 5%, 34.2 for the mid 90% and 38.9 nmol/L for the top 5% of serum calcium (Ptrend = 0.006), free estradiol levels were 0.88, 0.92 and 0.80 pg/ml (Ptrend = 0.048).
conclusionsThis link between calcium and sex steroid hormones, in particular the U-shaped pattern with SHBG, may, in part, explain why observational studies have found a link between serum calcium and risk of prostate cancer.
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