Genetic instability of modified stem cells - a first step towards malignant transformation?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

1. Altered genome induced immune response of iPSCs.Frontiers in immunology · 2026
   Article
2. Standardization of Cell Culture Conditions and Routine Genomic Screening under a Quality Management System Leads to Reduced Genomic Instability in hPSCs.Cells · 2022
   Article
3. Human ESC-derived Neuromesodermal Progenitors (NMPs) Successfully Differentiate into Mesenchymal Stem Cells (MSCs).Stem cell reviews and reports · 2022
   Article
4. Regenerative medicine applications: An overview of clinical trials.Frontiers in bioengineering and biotechnology · 2022
   Review
5. Perspective: Why and How Ubiquitously Distributed, Vascular-Associated, Pluripotent Stem Cells in the Adult Body (vaPS Cells) Are the Next Generation of Medicine.Cells · 2021
   Review
6. Acquired genetic changes in human pluripotent stem cells: origins and consequences.Nature reviews. Molecular cell biology · 2020
   Review
7. Advances in regenerative therapy: A review of the literature and future directions.Regenerative therapy · 2020
   Review
8. Stem cell therapy: old challenges and new solutions.Molecular biology reports · 2020
   Review
9. 21st Century Cell Culture for 21st Century Toxicology.Chemical research in toxicology · 2017
   Article
10. Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases.Molecular brain · 2016
    Article
11. Nuclear reprogramming with a non-integrating human RNA virus.Stem cell research & therapy · 2015
    Article
12. Molecular mechanism of extrinsic factors affecting anti-aging of stem cells.World journal of stem cells · 2015
    Review
13. Mesenchymal Stromal Cell-Derived Factors Promote Tissue Repair in a Small-for-Size Ischemic Liver Model but Do Not Protect against Early Effects of Ischemia and Reperfusion Injury.Journal of immunology research · 2015
    Article
14. Ethics of iPSC-based clinical research for age-related macular degeneration: patient-centered risk-benefit analysis.Stem cell reviews and reports · 2014
    Article
15. Interaction between nonviral reprogrammed fibroblast stem cells and trophic factors for brain repair.Molecular neurobiology · 2014
    Article
16. Stem cells in plastic surgery: a review of current clinical and translational applications.Archives of plastic surgery · 2013
    Review
17. Look back in anger - what clinical studies tell us about preclinical work.ALTEX · 2013
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

3 authors at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

Indexed as