ArticleInternational journal of preventive medicine2013
How much in vitro cholesterol reducing activity of lactobacilli predicts their in vivo cholesterol function?
Article in International journal of preventive medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Invitro and Invivo Analysis of Human Milk Lactic Acid Bacteria Isolates for Their Anti-hypercholesterolemia Actions.Indian journal of microbiology · 2024Article
- Assimilation of Cholesterol byJournal of fungi (Basel, Switzerland) · 2020Article
- Probiotic characteristics of Lactobacillus plantarum E680 and its effect on Hypercholesterolemic mice.BMC microbiology · 2020Article
- Probiotic Properties of Exopolysaccharide-Producing Lactobacillus Strains Isolated from Tempoyak.Molecules (Basel, Switzerland) · 2018Article
- Kefir: a multifaceted fermented dairy product.Probiotics and antimicrobial proteins · 2014Review
- Cholesterol assimilation by Lactobacillus probiotic bacteria: an in vitro investigation.BioMed research international · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBased on literature, in vitro cholesterol removal of lactic acid bacteria has been accounted for their in vivo cholesterol reduction. But recently it has been proposed that such in vitro characteristic may not be directly relevant to their in vivo activity. The objective of this study was to find how much in vitro cholesterol reducing potential of Lactobacillus plantarum A7 (LA7), a native strain isolated from an infant fecal flora, reflects its in vivo efficiency. LA7 previously showed serum cholesterol reducing capability in mice subjected to fatty diet. Here, we investigate whether the given strain is capable of in vitro cholesterol assimilation or consumption.
methodLA7 was cultured in whole milk and de-Man-Rogosa-Sharpe (MRS) added with water-soluble cholesterol. Colorimetric method was adopted for cholesterol determination in both cultured media during incubation period.
resultsNo cholesterol assimilation was detected by growth and incubation of the active culture in either of the medium. Thus, in vivo cholesterol function of LA7 was not caused by cholesterol consumption. A comprehensive review of literature on the related studies also showed that there are other documented studies which evidenced the uncertainty of the direct relation between in vitro and in vivo studies.
conclusionCholesterol removal from the cultured media may not be considered as an appropriate integral index for selection of Lactobacillus strains with cholesterol-lowering activity.
Indexed as
Identifiers
23671771PMC3650591What OpenQuestion holds
Registered trials
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