ArticlePloS one2013
Biological basis of miRNA action when their targets are located in human protein coding region.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- miR in melanoma development: miRNAs and acquired hallmarks of cancer in melanoma.Physiological genomics · 2013Pooled it
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- A synonymous mutation of rs1137070 cause the miceFrontiers in molecular neuroscience · 2024Article
- Turning off a few overexpressed genes in prostate cancer with microRNAs using a 7mer-seed match model.Journal of cancer research and clinical oncology · 2023Article
- Synonymous sites for accessibility around microRNA binding sites in bacterial spot and speck disease resistance genes of tomato.Functional & integrative genomics · 2023Article
- Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia.Frontiers in cell and developmental biology · 2022Review
- Improved Radiotherapy Sensitivity of Nasopharyngeal Carcinoma Cells by miR-29-3p Targeting COL1A1 3'-UTR.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- A Concise Review of MicroRNA Exploring the Insights of MicroRNA Regulations in Bacterial, Viral and Metabolic Diseases.Molecular biotechnology · 2017Review
- Integrated analysis of individual codon contribution to protein biosynthesis reveals a new approach to improving the basis of rational gene design.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- miR-185-3p regulates the invasion and metastasis of nasopharyngeal carcinoma by targeting WNT2BOncology letters · 2017Article
- miR-324-3p suppresses migration and invasion by targeting WNT2B in nasopharyngeal carcinoma.Cancer cell international · 2017Article
- MicroRNA-15a inhibits the growth and invasiveness of malignant melanoma and directly targets on CDCA4 gene.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Characterization of miR-206 Promoter and Its Association with Birthweight in Chicken.International journal of molecular sciences · 2016Article
- Comprehensive analysis of microRNA expression profile in malignant glioma tissues.Molecular oncology · 2015Article
- miR-185-3p regulates nasopharyngeal carcinoma radioresistance by targeting WNT2B in vitro.Cancer science · 2014Article
- Comprehensive luciferase-based reporter gene assay reveals previously masked up-regulatory effects of miRNAs.International journal of molecular sciences · 2014Article
- The role of RNA structure at 5' untranslated region in microRNA-mediated gene regulation.RNA (New York, N.Y.) · 2014Article
- The characterization of microRNA-mediated gene regulation as impacted by both target site location and seed match type.PloS one · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Recent analyses have revealed many functional microRNA (miRNA) targets in mammalian protein coding regions. But, the mechanisms that ensure miRNA function when their target sites are located in protein coding regions of mammalian mRNA transcripts are largely unknown. In this paper, we investigate some potential biological factors, such as target site accessibility and local translation efficiency. We computationally analyze these two factors using experimentally identified miRNA targets in human protein coding region. We find site accessibility is significantly increased in miRNA target region to facilitate miRNA binding. At the mean time, local translation efficiency is also selectively decreased near miRNA target region. GC-poor codons are preferred in the flank region of miRNA target sites to ease the access of miRNA targets. Within-genome analysis shows substantial variations of site accessibility and local translation efficiency among different miRNA targets in the genome. Further analyses suggest target gene's GC content and conservation level could explain some of the differences in site accessibility. On the other hand, target gene's functional importance and conservation level can affect local translation efficiency near miRNA target region. We hence propose both site accessibility and local translation efficiency are important in miRNA action when miRNA target sites are located in mammalian protein coding regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.