Evidence map›Paper›PMID 23671666›Full record

ArticlePloS one2013

Differential distribution of the Ca (2+) regulator Pcp4 in the branchial arches is regulated by Hoxa2.

Megan Anderson, Shilu Amin, Fabiana Luise, Leo Zeef, Nicoletta Bobola

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Conditional Loss ofFrontiers in molecular neuroscience · 2017
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Megan AndersonFaculty of Medical and Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.
Shilu Amin
Fabiana Luise
Leo Zeef
Nicoletta Bobola
Manchester Academic Health Science Centre · GBUniversity of Manchester · GB

Funding

Biotechnology and Biological Sciences Research Council BB/E017355/1Biotechnology and Biological Sciences Research Council BB/H018123/
6 · The paper itself

Abstract

Branchial arches are externally visible tissue bands in the head region of all vertebrate embryos. Although initially formed from similar components, each arch will give rise to different head and neck structures. In a screen designed to characterize the molecular control of branchial arch identity in mouse, we identified Pcp4 as a second branchial arch-specific molecular signature. We further show that the transcription factor Hoxa2 binds to Pcp4 chromatin and regulates Pcp4 expression in the second arch. Hoxa2 is also sufficient to induce Pcp4 expression in anterior first arch cells, which are Pcp4-negative.

Indexed as

Gene Expression ProfilingGene Expression Regulation, DevelopmentalAnimalsBranchial RegionCells, CulturedChromatin ImmunoprecipitationFluorescent Antibody TechniqueHomeodomain ProteinsMiceMice, KnockoutNerve Tissue ProteinsOligonucleotide Array Sequence AnalysisProtein BindingReverse Transcriptase Polymerase Chain ReactionHomeodomain ProteinsHoxa2 protein, mouseNerve Tissue ProteinsPcp4 protein, mouse

Identifiers

PMID23671666
PMCPMC3650044
OpenAlexW2088716269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.