ArticlePloS one2013
Perinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- MRI-based brain volumes of preterm infants at term: a systematic review and meta-analysis.Archives of disease in childhood. Fetal and neonatal edition · 2022Pooled it
- Multivariate analyses applied to fetal, neonatal and pediatric MRI of neurodevelopmental disorders.NeuroImage. Clinical · 2015Pooled it
- Postmenstrual age-adjusted brain volumes and their association with early neurodevelopmental outcomes in very low birth weight infants.Scientific reports · 2026Article
- Aperiodic parameters of the fMRI power spectrum associate with preterm birth and neonatal age.Communications biology · 2026Article
- Harmonization of slice thickness through resampling improves comparability of MRI-derived neonatal brain volumes.Frontiers in radiology · 2026Article
- Retinopathy of Prematurity and Risk of Structural Brain Abnormalities on Magnetic Resonance Imaging at Term Among Infants Born at Less Than or Equal to 32 Weeks of Gestation.The Journal of pediatrics · 2025Article
- Cerebellar Development and the Burden of Prematurity.Cerebellum (London, England) · 2025Review
- Gestational Duration and Postnatal Age-Related Changes in Aperiodic and Periodic Parameters in Neonatal and Toddler Electroencephalogram (EEG).Human brain mapping · 2025Article
- Effects of Early Enteral to Parenteral Protein Ratios on Brain Volume and Somatic Growth in Very Low Birth Weight Infants.The Journal of pediatrics · 2024Article
- Extremely Preterm Infants with a Near-total Absence of Cerebellum: Usefulness of Quantitative Magnetic Resonance in Predicting the Motor Outcome.Cerebellum (London, England) · 2024Article
- Clinical-functional correlation with brain volumetry in severe perinatal asphyxia: a case report.Italian journal of pediatrics · 2024Article
- Ultrasonographic evaluation of the early brain growth pattern in very low birth weight infants.Pediatric research · 2023Article
- Relationship between early nutrition and deep gray matter and lateral ventricular volumes of preterm infants at term-equivalent age.World journal of pediatrics : WJP · 2023Article
- Hearing, Speech, and Language in Infants and Toddlers Born Prematurely.The Volta review · 2023Article
- Early development of sleep and brain functional connectivity in term-born and preterm infants.Pediatric research · 2022Review
- Duration of mechanical ventilation is more critical for brain growth than postnatal hydrocortisone in extremely preterm infants.European journal of pediatrics · 2021Article
- Perinatal Risk and Protective Factors in the Development of Diffuse White Matter Abnormality on Term-Equivalent Age Magnetic Resonance Imaging in Infants Born Very Preterm.The Journal of pediatrics · 2021Article
- Preventing Brain Injury in the Preterm Infant-Current Controversies and Potential Therapies.International journal of molecular sciences · 2021Review
- Article
- Deep Multimodal Learning From MRI and Clinical Data for Early Prediction of Neurodevelopmental Deficits in Very Preterm Infants.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Our objective was to investigate diverse clinical antecedents of total and regional brain volume abnormalities and white matter hyperintensity volume on term MRI in extremely low birth weight (birth weight ≤1000 g) survivors. A consecutive cohort of extremely low birth weight infants who survived to 38 weeks postmenstrual age (n = 122) and a control group of 16 healthy term newborns underwent brain MRI at term-equivalent age. Brain volumes were measured using semi-automated and manual segmentation methods. Using multivariable linear regression, clinical antecedents were correlated with volumes of total brain tissue, white matter hyperintensities, and regional tissues/structures, adjusted for age at MRI, total cranial volume, and total tissue volume. Regional brain volumes were markedly reduced in extremely low birth weight infants as compared to term newborns (relative difference range: -11.0%, -35.9%). Significant adverse clinical associations for total brain tissue volume included: small for gestational age, seizures, caffeine therapy/apnea of prematurity, duration of parenteral nutrition, pulmonary hemorrhage, and white matter injury (p<0.01 for each; relative difference range: -1.4% to -15.0%). Surgery for retinopathy of prematurity and surgery for necrotizing enterocolitis or spontaneous intestinal perforation were significantly associated with increasing volume of white matter hyperintensities. Regional brain volumes are sensitive to multiple perinatal factors and neonatal morbidities or interventions. Brain growth measurements in extremely low birth weight infants can advance our understanding of perinatal brain injury and development.
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Registered trials
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