ArticleArchives of medical science : AMS2013
Contrast imaging and gene delivery through the combined use of novel cationic liposomal microbubbles and ultrasound in rat carotid arteries.
Article in Archives of medical science : AMS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 citing papers in PubMed, 3 citations in OpenAlex.
- The effect of osteoprotegerin on implant osseointegration in ovariectomized rats.Archives of medical science : AMS · 2017Article
- Galactosylated poly-L-lysine targeted microbubbles for ultrasound mediated antisense c-myc gene transfection in hepatocellular carcinoma cells.Archives of medical science : AMS · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionLipid-coated cationic microbubbles represent a new class of agents with both diagnostic and therapeutic applications. The main goal of this study was to evaluate the efficiency of gene transfer through the combined use of microbubbles and ultrasound in rat carotid arteries. Furthermore, we assessed whether the cationic liposomal microbubbles could allow long-term enhanced imaging, comparing with SonoVue(®). MATERIAL AND
methodsNormal rat carotid arteries were imaged after intravenous bolus injections of 0.5 ml/kg of two contrast agents (SonoVue(®) and the cationic liposomal microbubbles). Forty Sprague-Dawley rats were divided into 5 groups according to ultrasound parameters and were treated with or without microbubbles. All rats were sacrificed after being transfected for 2 days. The level of protein expression was determined by western blot analysis.
resultsThe enhancing time of self-made microbubbles was much longer than that of SonoVue(®) in rat carotid arteries (p < 0.05). The results of the western blot analysis revealed that the expression of SR-BI DNA in the carotid artery was highest in the SR-BI + US/CLM group (p < 0.05).
conclusionsThese results suggest that the novel cationic liposomal microbubbles enhance image quality over a longer period than does SonoVue(®). Additionally, the combination of ultrasound and this new type of microbubble can act synergistically to increase SR-BI DNA transfection.
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