ArticlePLoS computational biology2013
Selection for replicases in protocells.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Experimental evolution toward extinction in a molecular host-parasite system.Molecular biology and evolution · 2026Article
- Compositional memory matters for early molecular systems.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The secret life of RNA and lipids.RNA biology · 2025Review
- Biomathematical enzyme kinetics model of prebiotic autocatalytic RNA networks: degenerating parasite-specific hyperparasite catalysts confer parasite resistance and herald the birth of molecular immunity.PLoS computational biology · 2025Article
- Rolling Circles as a Means of Encoding Genes in the RNA World.Life (Basel, Switzerland) · 2022Article
- The Effect of Environment on the Evolution and Proliferation of Protocells of Increasing Complexity.Life (Basel, Switzerland) · 2022Article
- Lipid membranes modulate the activity of RNA through sequence-dependent interactions.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Evolution towards increasing complexity through functional diversification in a protocell model of the RNA world.Proceedings. Biological sciences · 2021Article
- Natural selection in compartmentalized environment with reshuffling.Journal of mathematical biology · 2019Article
- Survival of RNA Replicators is much Easier in Protocells than in Surface-Based, Spatial Systems.Life (Basel, Switzerland) · 2019Article
- The evolutionary dynamics of metabolic protocells.PLoS computational biology · 2018Article
- Environmental Adaptation from the Origin of Life to the Last Universal Common Ancestor.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2018Article
- Primordial sex facilitates the emergence of evolution.Journal of the Royal Society, Interface · 2018Article
- Kin Selection in the RNA World.Life (Basel, Switzerland) · 2017Article
- Toy trains, loaded dice and the origin of life: dimerization on mineral surfaces under periodic drive with Gaussian inputs.Royal Society open science · 2017Article
- The evolution of cooperation in simple molecular replicators.Proceedings. Biological sciences · 2017Article
- Prebiotic selection for motifs in a model of template-free elongation of polymers within compartments.PloS one · 2017Article
- Co-operation between Polymerases and Nucleotide Synthetases in the RNA World.PLoS computational biology · 2016Article
- Evolutionarily stable disequilibrium: endless dynamics of evolution in a stationary population.Proceedings. Biological sciences · 2016Article
- Hypercycle.PLoS computational biology · 2016Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We consider a world of nucleotide sequences and protocells. The sequences have the property of spontaneous self-replication. Some sequences - so-called replicases - have enzymatic activity in the sense of enhancing the replication rate of all (or almost all) sequences. In a well-mixed medium, natural selection would not favor such replicases because their presence equally benefits sequences with or without replicase activity. Here we show that protocells can select for replicases. We assume that sequences replicate within protocells and that protocells undergo spontaneous division. This leads to particular population structures which can augment the abundance of replicases. We explore various assumptions regarding replicase activity and protocell division. We calculate the error threshold that is compatible with selecting for replicases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.