ArticleJournal of asthma and allergy2013
Incidence and risk factors for exacerbations of asthma during pregnancy.
Article in Journal of asthma and allergy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Asthma Control During Pregnancy and Adverse Perinatal Outcomes: A Systematic Review.The Australian & New Zealand journal of obstetrics & gynaecology · 2026Pooled it
- Prenatal Exposure to Fine Particulate Matter Components and Autism Risk in Childhood.JAMA network open · 2025Article
- Asthma Exacerbation Risk in Pregnancy and Postpartum: Assessing the Impact of Gestational Diabetes Mellitus and Other Key Factors.The journal of allergy and clinical immunology. In practice · 2025Article
- Breathing for Two: Asthma Management, Treatment, and Safety of Pharmacological Therapy during Pregnancy.Medicines (Basel, Switzerland) · 2024Review
- Treatable Traits in Pregnant Women with Asthma.Respiration; international review of thoracic diseases · 2024Review
- Treatable traits in asthma during pregnancy: a call for a shift towards a precision-based management approach.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Characterizing the neuroimmune environment of offspring in a novel model of maternal allergic asthma and particulate matter exposure.Journal of neuroinflammation · 2023Article
- Maternal Allergic Asthma Induces Prenatal Neuroinflammation.Brain sciences · 2022Article
- The Hidden Burden of Severe Asthma: From Patient Perspective to New Opportunities for Clinicians.Journal of clinical medicine · 2020Review
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- Sex-specific impact of asthma during pregnancy on infant gut microbiota.The European respiratory journal · 2017Article
- All that wheezes is not asthma: A cautionary case study of shortness of breath in pregnancy.Obstetric medicine · 2015Article
- Passive smoking is associated with poor asthma control during pregnancy: a prospective study of 500 pregnancies.PloS one · 2014Observational
- The Association of Maternal Asthma and Early Pregnancy Vitamin D with Risk of Preeclampsia: An Observation From Vitamin D Antenatal Asthma Reduction Trial (VDAART).The journal of allergy and clinical immunology. In practiceArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma is one of the most common chronic diseases among pregnant women. Acute exacerbations of asthma during pregnancy have an unfavorable impact on pregnancy outcome. This review provides an overview of current knowledge of incidence, mechanisms, and risk factors for acute exacerbations of asthma during pregnancy.
methodsA narrative literature review was carried out using the PubMed database.
resultsDuring pregnancy, up to 6% of women with asthma are hospitalized for an acute exacerbation. The maternal immune system is characterized by a very high T-helper-2:T-helper-1 cytokine ratio during pregnancy and thereby provides an environment essential for fetal survival but one that may aggravate asthma. Cells of the innate immune system such as monocytes and neutrophils are also increased during pregnancy, and this too can exacerbate maternal asthma. Severe or difficult-to-control asthma appears to be the major risk factor for exacerbations during pregnancy, but studies also suggest that nonadherence with controller medication and viral infections are important triggers of exacerbations during pregnancy. So far, inconsistent findings have been reported regarding the effect of fetal sex on exacerbations during pregnancy. Other risk factors for exacerbation during pregnancy include obesity, ethnicity, and reflux, whereas atopy does not appear to be a risk factor. DISCUSSION: The incidence of asthma exacerbations during pregnancy is disturbingly high. Severe asthma - better described as difficult-to-control asthma - nonadherence with controller therapy, viral infections, obesity, and ethnicity are likely to be important risk factors for exacerbations of asthma during pregnancy, whereas inconsistent findings have been reported with regard to the importance of sex of the fetus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.