ArticleProceedings of the National Academy of Sciences of the United States of America2013
Concordant mast cell and basophil production by individual hematopoietic blast colony-forming cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Human HSPC clones balance stochastic diversification with cytokine-induced differentiation.Blood · 2026Article
- Transcriptional Regulation of Mouse Mast Cell Differentiation and the Role of Human Lung Mast Cells in Airway Inflammation.Immunological reviews · 2025Review
- Novel insights into the ontogeny of basophils.Frontiers in allergy · 2024Review
- Single-cell molecular profiling provides a high-resolution map of basophil and mast cell development.Allergy · 2021Article
- Novel adherent CD11bOncotarget · 2018Article
- Bone marrow basophils provide survival signals to immature B cells in vitro but are dispensable in vivo.PloS one · 2017Article
- Transcriptional regulation of mast cell and basophil lineage commitment.Seminars in immunopathology · 2016Review
- Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation.The Journal of biological chemistry · 2015Article
- Mechanisms controlling mast cell and basophil lineage decisions.Current allergy and asthma reports · 2014Review
- GATA-1 regulates the generation and function of basophils.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown that mouse bone marrow cells can produce mast cells when stimulated in vitro by stem cell factor (SCF) and interleukin-3 (IL-3). Experiments to define the marrow cells able to generate mast cells showed that the most active subpopulations were the Kit(+) Sca1(-) progenitor cell fraction and the more ancestral Kit(+) Sca1(+) blast colony-forming cell fraction. In clonal cultures, up to 64% of blast colony-forming cells were able to generate mast cells when stimulated by SCF and IL-3, and, of these, the most active were those in the CD34(-) Flt3R(-) long-term repopulating cell fraction. Basophils, identified by the monoclonal antibody mMCP-8 to mouse mast cell serine protease-8, were also produced by 50% of blast colony-forming cells with a strong concordance in the production of both cell types by individual blast colony-forming cells. Enriched populations of marrow-derived basophils were shown to generate variable numbers of mast cells after a further incubation with SCF and IL-3. The data extend the repertoire of lineage-committed cells able to be produced by multipotential hematopoietic blast colony-forming cells and show that basophils and mast cells can have common ancestral cells and that basophils can probably generate mast cells at least under defined in vitro conditions.
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