ArticleProceedings of the National Academy of Sciences of the United States of America2013
Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 86 citations in OpenAlex.
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- Fluorescence molecular optomic signatures improve identification of tumors in head and neck specimens.Frontiers in medical technology · 2023Article
- Development of a theranostic preclinical fluorescence molecular tomography/cone beam CT-guided irradiator platform.Biomedical optics express · 2022Article
- Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography.Biomedical optics express · 2022Article
- Examining the Feasibility of Quantifying Receptor Availability Using Cross-Modality Paired-Agent Imaging.Molecular imaging and biology · 2022Article
- Recent Technical Advances in Accelerating the Clinical Translation of Small Animal Brain Imaging: Hybrid Imaging, Deep Learning, and Transcriptomics.Frontiers in medicine · 2022Review
- Macroscopic Fluorescence Lifetime Imaging for Monitoring of Drug-Target Engagement.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A review of the application of machine learning in molecular imaging.Annals of translational medicine · 2021Review
- A hyperspectral approach for recovering agent excretion biodistributions using whole-body fluorescence cryo-imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2021Article
- Monitoring cancer cell surface receptor expression during anti-angiogenesis therapy in vivo.Proceedings of SPIE--the International Society for Optical Engineering · 2021Article
- Small-animal 360-deg fluorescence diffuse optical tomography using structural prior information from ultrasound imaging.Journal of biomedical optics · 2020Article
- A paired-agent fluorescent molecular imaging strategy for quantifying antibody drug target engagement inProceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Kinetic modeling and analysis of dynamic bioluminescence imaging of substrates administered by intraperitoneal injection.Quantitative imaging in medicine and surgery · 2020Article
- Developing a novel hyperspectral imaging cryomacrotome for whole body fluorescence imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Noninvasive quantification of target availability during therapy using paired-agent fluorescence tomography.Theranostics · 2020Article
- Estimating paired-agent uptake in altered tumor vasculature using MRI-coupled fluorescence tomography.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Estimating drug delivery using hybrid system for simultaneous dynamic MRI and fluorescence tomography.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Simultaneous extracellular and intracellular quantification of EGFR using paired-agent imaging in anProceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Paired-agent imaging for detection of head and neck cancers.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The up-regulation of cell surface receptors has become a central focus in personalized cancer treatment; however, because of the complex nature of contrast agent pharmacokinetics in tumor tissue, methods to quantify receptor binding in vivo remain elusive. Here, we present a dual-tracer optical technique for noninvasive estimation of specific receptor binding in cancer. A multispectral MRI-coupled fluorescence molecular tomography system was used to image the uptake kinetics of two fluorescent tracers injected simultaneously, one tracer targeted to the receptor of interest and the other tracer a nontargeted reference. These dynamic tracer data were then fit to a dual-tracer compartmental model to estimate the density of receptors available for binding in the tissue. Applying this approach to mice with deep-seated gliomas that overexpress the EGF receptor produced an estimate of available receptor density of 2.3 ± 0.5 nM (n = 5), consistent with values estimated in comparative invasive imaging and ex vivo studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.