Evidence map›Paper›PMID 23671057›Full record

ArticleObesity (Silver Spring, Md.)2013

Skeletal muscle adiposity is associated with serum lipid and lipoprotein levels in Afro-Caribbean men.

I Miljkovic, A L Kuipers, L H Kuller, Y Sheu, C H Bunker, A L Patrick, V W Wheeler, R W Evans, J M Zmuda

Open access · bronzeAbstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Intermuscular adipose tissue in metabolic disease.Nature reviews. Endocrinology · 2023
    Review
  6. Article
  7. Article
  8. Changes in Body Composition, Muscle Strength, and Fat Distribution Following Kidney Transplantation.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021
    Article
  9. Review
  10. Article
  11. Review
  12. Racial and Ethnic Heterogeneity in the Association Between Total Cholesterol and Pediatric Obesity.International journal of environmental research and public health · 2015
    Article
  13. Lower-extremity muscle atrophy and fat infiltration after chronic spinal cord injury.Journal of musculoskeletal & neuronal interactions · 2015
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

I MiljkovicDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
A L Kuipers
L H Kuller
Y Sheu
C H Bunker
A L Patrick
V W Wheeler
R W Evans
J M Zmuda
University of Pittsburgh · USUniversity of Trinidad and Tobago · TT

Funding

Cardiovascular Epidemiology Training ProgramT32HL083825 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AKIRA SEKIKAWA · 2008 to 2026
$6.1M
Epidemiology of Bone Loss in African MenR01AR049747 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZMUDA, JOSEPH M. · 2003 to 2014
$5.9M
Epidemiology and Genetics of Skeletal Muscle CompositionK01DK083029 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MILJKOVIC, IVA · 2008 to 2012
$640k
Determinants of Bone Strength in Afro-Caribbean FamiliesR03AR050107 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZMUDA, JOSEPH M · 2003 to 2004
$149k
NHLBI NIH HHS T32 HL083825NHLBI NIH HHS T32-HL083825NIAMS NIH HHS R01 AR049747NIAMS NIH HHS R01-AR049747NIAMS NIH HHS R03 AR050107NIAMS NIH HHS R03-AR050107NIDDK NIH HHS K01 DK083029NIDDK NIH HHS K01-DK083029
6 · The paper itself

Abstract

objectiveWhen compared with other ethnic groups, African ancestry individuals have lower triglycerides and higher High-density lipoprotein cholesterol (HDL-C) levels, although the mechanisms for these differences remain unclear. A comprehensive array of factors potentially related to fasting serum lipid and lipoprotein levels in African ancestry men was evaluated. DESIGN AND

methodsMen (1,821) underwent dual-energy X-ray absorptiometry measures of total body fat and quantitative computed tomography assessments of calf skeletal muscle adiposity [subcutaneous and intermuscular adipose tissue (AT), and muscle density as a measure of intra-muscular AT].

resultsMultivariable linear regression analysis identified age (-), total body fat (+), subcutaneous AT (-), fasting glucose (+), fasting insulin (+), diastolic blood pressure (+), and non-African ancestry (+) as independent correlates of triglycerides (all P < 0.05). Total body fat (+), intra-muscular AT (-), and diastolic blood pressure (+) were independent correlates of Low-density lipoprotein cholesterol (LDL-C) (all P < 0.001). Age (+), waist circumference (-), fasting insulin (-), physical activity (+), and alcohol intake (+) were independent correlates of HDL-C (all P < 0.05).

conclusionsA novel relationship between skeletal muscle adiposity and serum lipid and lipoprotein levels in African ancestry men, independent of total and central adiposity was illuminated. In African ancestry populations, genetic factors are likely a significant determinant of triglycerides levels.

Indexed as

AdiposityBlack PeopleAdipose TissueAgedAge FactorsBlood GlucoseBlood PressureCaribbean RegionCholesterol, HDLCholesterol, LDLHumansInsulinLegLife StyleLipoproteinsMaleBlood GlucoseCholesterol, HDLCholesterol, LDLInsulinLipoproteinsTriglycerides

Identifiers

PMID23671057
PMCPMC3748155
OpenAlexW1764857967

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.