ArticleHuman brain mapping2014
Mapping neurotransmitter networks with PET: an example on serotonin and opioid systems.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 55 citations in OpenAlex.
- Inter-individual variability of neurotransmitter receptor and transporter density in the human brain.Brain structure & function · 2026Article
- AI-enabled multimodal neuroimaging for neurotransmitter mapping in normal aging and age-related disease.Frontiers in aging neuroscience · 2026Review
- Molecular connectivity studies in neurotransmission: a scoping review.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Endogenous opioid receptor system mediates costly altruism in the human brain.Communications biology · 2024Article
- Dopamine D1-Receptor Organization Contributes to Functional Brain Architecture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- From neurotransmitters to networks: Transcending organisational hierarchies with molecular-informed functional imaging.Neuroscience and biobehavioral reviews · 2023Review
- Brain connectomics: time for a molecular imaging perspective?Trends in cognitive sciences · 2023Review
- Significance of an Electrochemical Sensor and Nanocomposites: Toward the Electrocatalytic Detection of Neurotransmitters and Their Importance within the Physiological System.ACS nanoscience Au · 2023Review
- Neurotransmitter receptor densities are associated with changes in regional Cerebral blood flow during clinical ongoing pain.Human brain mapping · 2022Article
- Identifying the individual metabolic abnormities from a systemic perspective using whole-body PET imaging.European journal of nuclear medicine and molecular imaging · 2022Article
- Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators.Nature reviews. Neuroscience · 2022Review
- Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HTMolecules (Basel, Switzerland) · 2022Article
- μ-opioid receptor availability is associated with sex drive in human males.Cognitive, affective & behavioral neuroscience · 2022Article
- Obesity risk is associated with altered cerebral glucose metabolism and decreased μ-opioid and CBInternational journal of obesity (2005) · 2022Article
- NRM 2021 Abstract Booklet.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Cerebral μ-opioid and CBTranslational psychiatry · 2021Article
- Seasonal Variation in the Brain μ-Opioid Receptor Availability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Lowered endogenous mu-opioid receptor availability in subclinical depression and anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- From metabolic connectivity to molecular connectivity: application to dopaminergic pathways.European journal of nuclear medicine and molecular imaging · 2020Article
- Reduced mu opioid receptor availability in schizophrenia revealed with [Nature communications · 2019Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All functions of the human brain are consequences of altered activity of specific neural pathways and neurotransmitter systems. Although the knowledge of "system level" connectivity in the brain is increasing rapidly, we lack "molecular level" information on brain networks and connectivity patterns. We introduce novel voxel-based positron emission tomography (PET) methods for studying internal neurotransmitter network structure and intercorrelations of different neurotransmitter systems in the human brain. We chose serotonin transporter and μ-opioid receptor for this analysis because of their functional interaction at the cellular level and similar regional distribution in the brain. Twenty-one healthy subjects underwent two consecutive PET scans using [(11)C]MADAM, a serotonin transporter tracer, and [(11)C]carfentanil, a μ-opioid receptor tracer. First, voxel-by-voxel "intracorrelations" (hub and seed analyses) were used to study the internal structure of opioid and serotonin systems. Second, voxel-level opioid-serotonin intercorrelations (between neurotransmitters) were computed. Regional μ-opioid receptor binding potentials were uniformly correlated throughout the brain. However, our analyses revealed nonuniformity in the serotonin transporter intracorrelations and identified a highly connected local network (midbrain-striatum-thalamus-amygdala). Regionally specific intercorrelations between the opioid and serotonin tracers were found in anteromedial thalamus, amygdala, anterior cingulate cortex, dorsolateral prefrontal cortex, and left parietal cortex, i.e., in areas relevant for several neuropsychiatric disorders, especially affective disorders. This methodology enables in vivo mapping of connectivity patterns within and between neurotransmitter systems. Quantification of functional neurotransmitter balances may be a useful approach in etiological studies of neuropsychiatric disorders and also in drug development as a biomarker-based rationale for targeted modulation of neurotransmitter networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.