ArticleCurrent protocols in toxicology2013
Simultaneous, untargeted metabolic profiling of polar and nonpolar metabolites by LC-Q-TOF mass spectrometry.
Article in Current protocols in toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Mass-spectrometry based metabolomics: an overview of workflows, strategies, data analysis and applications.Proteome science · 2025Review
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- Gut microbiota metabolically mediate intestinal helminth infection in Zebrafish.bioRxiv : the preprint server for biology · 2024Article
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- Effects of 5-ion 6-beam sequential irradiation in the presence and absence of hindlimb or control hindlimb unloading on behavioral performances and plasma metabolic pathways of Fischer 344 rats.Frontiers in physiology · 2024Article
- Article
- Effects of photon irradiation in the presence and absence of hindlimb unloading on the behavioral performance and metabolic pathways in the plasma of Fischer rats.Frontiers in physiology · 2023Article
- Embryonic Arsenic Exposure Triggers Long-Term Behavioral Impairment with Metabolite Alterations in Zebrafish.Toxics · 2022Article
- Multi-omics study identifies novel signatures of DNA/RNA, amino acid, peptide, and lipid metabolism by simulated diabetes on coronary endothelial cells.Scientific reports · 2022Article
- A High Throughput Lipidomics Method UsingBiomolecules · 2022Article
- ApoE isoform-dependent effects of xanthohumol on high fat diet-induced cognitive impairments and hippocampal metabolic pathways.Frontiers in pharmacology · 2022Article
- The Impact of the hAPP695SW Transgene and Associated Amyloid-β Accumulation on Murine Hippocampal Biochemical Pathways.Journal of Alzheimer's disease : JAD · 2022Article
- Nutritional Metabolomics and the Classification of Dietary Biomarker Candidates: A Critical Review.Advances in nutrition (Bethesda, Md.) · 2021Review
- Article
- Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice.Environmental health perspectives · 2021Article
- Effects of 5-Ion Beam Irradiation and Hindlimb Unloading on Metabolic Pathways in Plasma and Brain of Behaviorally Tested WAG/Rij Rats.Frontiers in physiology · 2021Article
- Article
- Ultrahigh-Resolution Mass Spectrometry-Based Platform for Plasma Metabolomics Applied to Type 2 Diabetes Research.Journal of proteome research · 2021Article
- Review
- Flavescence Dorée-Derived Leaf Yellowing in Grapevine (Frontiers in plant science · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
At its most ambitious, untargeted metabolomics aims to characterize and quantify all of the metabolites in a given system. Metabolites are often present at a broad range of concentrations and possess diverse physical properties complicating this task. Performing multiple sample extractions, concentrating sample extracts, and using several separation and detection methods are common strategies to overcome these challenges but require a great amount of resources. This protocol describes the untargeted, metabolic profiling of polar and nonpolar metabolites with a single extraction and using a single analytical platform.
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Registered trials
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