Evidence map›Paper›PMID 23670710›Full record

ArticleAIDS and behavior2013

How does antiretroviral treatment attenuate the stigma of HIV? Evidence from a cohort study in rural Uganda.

Alexander C Tsai, David R Bangsberg, Mwebesa Bwana, Jessica E Haberer, Edward A Frongillo, Conrad Muzoora, Elias Kumbakumba, Peter W Hunt, Jeffrey N Martin, Sheri D Weiser

Abstract read
In one paragraph

Article in AIDS and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  11. Effective Messages to Reduce Stigma among People Newly Diagnosed with HIV during Rapid ART Initiation.International journal of environmental research and public health · 2024
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  14. "African geographical review · 2024
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander C TsaiChester M. Pierce, MD Division of Global Psychiatry, Department of Psychiatry, Massachusetts General Hospital (MGH), Center for Global Health, Room 1529-E3, 100 Cambridge Street, 15th floor, Boston, MA, 02114, USA, actsai@partners.org.
David R Bangsberg
Mwebesa Bwana
Jessica E Haberer
Edward A Frongillo
Conrad Muzoora
Elias Kumbakumba
Peter W Hunt
Jeffrey N Martin
Sheri D Weiser

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
TB PREVENTION AND HIV IN THE HOMELESS--AN INTERVENTIONR01MH054907 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BANGSBERG, DAVID ROY · 1995 to 2014
$20.7M
Microenterprise to empower and improve health of HIV+ women in UgandaK23MH096620 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI TSAI, ALEXANDER C · 2012 to 2016
$922k
The Impact of Food Insecurity on HIV Outcomes and Sexual Risk Behavior in UgandaK23MH079713 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WEISER, SHERI DAWN · 2007 to 2011
$921k
Novel Measures and Theory of Pediatric Antiretroviral Therapy Adherence in UgandaK23MH087228 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI HABERER, JESSICA ELIZABETH · 2009 to 2013
$916k
Mentoring Patient Oriented Adherence Research in UgandaK24MH087227 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BANGSBERG, DAVID ROY · 2009 to 2013
$776k
NIAID NIH HHS P30 AI-027763NIAID NIH HHS P30 AI027763NIMH NIH HHS K23 MH-079713NIMH NIH HHS K23 MH079713NIMH NIH HHS K23 MH-079713-03S1NIMH NIH HHS K23 MH-087228NIMH NIH HHS K23 MH087228NIMH NIH HHS K23 MH-096620NIMH NIH HHS K23 MH096620NIMH NIH HHS K24 MH-087227NIMH NIH HHS K24 MH087227NIMH NIH HHS R01 MH-054907NIMH NIH HHS R01 MH054907
6 · The paper itself

Abstract

Program implementers and qualitative researchers have described how increasing availability of HIV antiretroviral therapy (ART) is associated with improvements in psychosocial health and internalized stigma. To determine whether, and through what channels, ART reduces internalized stigma, we analyzed data from 262 HIV-infected, treatment-naïve persons in rural Uganda followed from ART initiation over a median of 3.4 years. We fitted Poisson regression models with cluster-correlated robust estimates of variance, specifying internalized stigma as the dependent variable, adjusting for time on treatment as well as socio-demographic, clinical, and psychosocial variables. Over time on treatment, internalized stigma declined steadily, with the largest decline observed during the first 2 years of treatment. This trend remained statistically significant after multivariable adjustment (χ(2) = 28.3; P = 0.03), and appeared to be driven by ART-induced improvements in HIV symptom burden, physical and psychological wellbeing, and depression symptom severity.

Indexed as

DepressionSocial StigmaAdultAnti-HIV AgentsCohort StudiesDrug MonitoringFemaleHIV InfectionsHumansMaleMedication AdherenceMental HealthRural PopulationSeverity of Illness IndexTruth DisclosureUgandaAnti-HIV Agents

Identifiers

PMID23670710
PMCPMC3773278

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.