ArticleClinical orthopaedics and related research2013
Percutaneous doxycycline treatment of aneurysmal bone cysts with low recurrence rate: a preliminary report.
Article in Clinical orthopaedics and related research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05696834 (Sclerotherapy With Adjuvant Bone Marrow Injection In Management of Aneurysmal Bone Cyst), which is not on this map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sclerotherapy With Adjuvant Bone Marrow Injection In Management of Aneurysmal Bone Cyst
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- Percutaneous treatments of primary aneurysmal bone cysts: systematic review and meta-analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2021Pooled it
- Spinal aneurysmal bone cysts in children - institutional chart review and recommendation for treatment.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- The best solution is the simplest: advances in surgical and minimally invasive management of aneurysmal and simple bone cysts.Journal of orthopaedic surgery and research · 2026Review
- Article
- Management of spinal aneurysmal bone cyst: A case report.Surgical neurology international · 2026Article
- Patterns and Timing of Local Recurrence in Benign Bone Tumors.The Iowa orthopaedic journal · 2026Article
- Long term surgical results of cases with aneurysmal bone cysts-a comprehensive clinical, functional and oncologic analysis.BMC musculoskeletal disorders · 2025Article
- Aneurysmal bone cysts (ABC): Retrospective analysis of two hundred and fifty eight cases.International orthopaedics · 2025Article
- Cystic bone Lesions: Diagnostic pitfalls and therapeutic considerations.Journal of clinical orthopaedics and trauma · 2025Review
- Percutaneous Management of Benign Bone Cysts and Tumors in Children.Seminars in interventional radiology · 2025Review
- Novel Clinical Practice Assessments: Informational Statements by the Musculoskeletal Tumor Society.Journal of surgical oncology · 2025Review
- A 20-Year-Old Woman with Metachronous Polyostotic Simple (Unicameral) Bone Cysts in 9 Sites: A Case Report.The American journal of case reports · 2025Article
- Transoral resection of a symptomatic odontoid process aneurysmal bone cyst: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- A Rare Case of a Solid Variant Aneurysmal Bone Cyst of the Medial Sphenoid Bone: Clinical Features, Diagnostic Points, and Treatment.NMC case report journal · 2025Article
- Percutaneous Doxycycline Ablation for Recurrent Aneurysmal Bone Cyst in the Sacroiliac Joint: A Case Report.Journal of orthopaedic case reports · 2024Article
- A New Radiological Scoring System as a Method of Assessing Sclerotherapy Treatment Response for Aneurysmal Bone Cysts: A Retrospective Study.The Indian journal of radiology & imaging · 2024Article
- Modern treatment of unicameral and aneurysmatic bone cysts.EFORT open reviews · 2024Review
- Review
- Management of aggressive recurrent thoracic spine aneurysmal bone cyst in a 7-year-old male: A case report and review of the literature.Surgical neurology international · 2024Article
- Efficacy of Percutaneous Treatment of Primary Aneurysmal Bone Cysts (ABCs): A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAneurysmal bone cyst (ABC) has a recurrence rate of between 12% and 71% without en bloc resection or amputation. There is no percutaneous ABC treatment drug regimen demonstrating consistent evidence of bone healing with recurrence of < 12%. Doxycycline has properties that may make it appropriate for percutaneous treatment. QUESTIONS/PURPOSES: We therefore asked: (1) Is there reduction in ABC lytic cyst volume with injectable doxycycline? (2) Is it associated with thickening of involved bony cortex? (3) Is the recurrence rate after percutaneous treatment < 12%?
methodsWe retrospectively reviewed 20 patients who underwent percutaneous treatment of ABCs with doxycycline from 2006 to 2010. The mean age was 10 years (range, 3-18 years). There were 21 treatment locations: humerus (six), spine (five), clavicle (two), fibula (one), femur (two), ulna (two), tibia (two), and scapula (one). Twenty patients completed treatment involving 118 treatment sessions (two to 14 sessions per patient). Treatment response was evaluated radiographically by measuring the lytic component and thickness of involved cortex. Recurrence was indicated by new areas of lytic destruction after completion of treatment. The minimum followup was 24 months (mean, 38 months).
resultsTwenty of 20 patients demonstrated reduction in lytic destruction and bony healing. All patients demonstrated cortical thickening. One patient demonstrated recurrent minimal lytic destruction after 20 months of observation.
conclusionsIn this series, patients undergoing percutaneous doxycycline treatment of ABCs demonstrated a healing response and a recurrence rate of 5% at more than 24 months.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.