ArticleElectrophoresis2013
Encapsulated electrodes for microchip devices: microarrays and platinized electrodes for signal enhancement.
Article in Electrophoresis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
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- A 3D-printed, multi-modal microfluidic device for measuring nitric oxide and ATP release from flowing red blood cells.Analytical methods : advancing methods and applications · 2022Article
- Red blood cells in type 1 diabetes and multiple sclerosis and technologies to measure their emerging roles.Journal of translational autoimmunity · 2022Review
- Fully 3D printed fluidic devices with integrated valves and pumps for flow injection analysis.Analytical methods : advancing methods and applications · 2021Article
- Biological applications of microchip electrophoresis with amperometric detection: in vivo monitoring and cell analysis.Analytical and bioanalytical chemistry · 2020Review
- Direct embedding and versatile placement of electrodes in 3D printed microfluidic-devices.The Analyst · 2020Article
- Microfluidic device using a gold pillar array and integrated electrodes for on-chip endothelial cell immobilization, direct RBC contact, and amperometric detection of nitric oxide.Electroanalysis · 2019Article
- Optimization of a microchip electrophoresis method with electrochemical detection for the determination of nitrite in macrophage cells as an indicator of nitric oxide production.Analytical methods : advancing methods and applications · 2019Article
- Use of 3D Printing and Modular Microfluidics to Integrate Cell Culture, Injections and Electrochemical Analysis.Analytical methods : advancing methods and applications · 2018Article
- Microchip-based electrochemical detection using a 3-D printed wall-jet electrode device.The Analyst · 2016Article
- Alkyl-Nitrile Adlayers as Probes of Plasmonically Induced Electric Fields.Chemical science · 2015Article
- Sheath-flow microfluidic approach for combined surface enhanced Raman scattering and electrochemical detection.Analytical chemistry · 2015Article
- Fabrication and Characterization of All-Polystyrene Microfluidic Devices with Integrated Electrodes and Tubing.Analytical methods : advancing methods and applications · 2015Article
- Microfluidic device with tunable post arrays and integrated electrodes for studying cellular release.The Analyst · 2014Article
- 3D printed microfluidic devices with integrated versatile and reusable electrodes.Lab on a chip · 2014Article
- A reusable electrochemical proximity assay for highly selective, real-time protein quantitation in biological matrices.Journal of the American Chemical Society · 2014Article
- Micro total analysis systems: fundamental advances and biological applications.Analytical chemistry · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this paper, we present two new methodologies of improving the performance of microchip-based electrochemical detection in microfluidic devices. The first part describes the fabrication and characterization of epoxy-embedded gold microelectrode arrays that are evenly spaced and easily modified. Electrodepositions using a gold plating solution can be performed on the electrodes to result in a 3D pillar array that, when used with microchip-based flow injection analysis, leads to an eightfold increase in signal (when compared to a single electrode), with the LOD for catechol being 4 nM. For detecting analytically challenging molecules such as nitric oxide (NO), platinization of electrodes is commonly used to increase the sensitivity. It is shown here that microchip devices containing either the pillar arrays or more traditional glassy carbon electrodes can be modified with platinum black (Pt-black) for NO detection. In the case of using glassy carbon electrodes for NO detection, integration of the resulting platinized electrode with microchip-based flow analysis resulted in a ten times signal increase relative to use of a bare glassy carbon electrode. In addition, it is demonstrated that these electrodes can be coated with Nafion to impart selectivity toward NO over interfering species such as nitrite. The LOD for NO when using the Pt-black /Nafion-coated glassy carbon electrode was 9 nM. These electrodes can also be embedded in a polystyrene substrate, with the applicability of these sensitive and selective electrodes being demonstrated by monitoring the adenosine triphosphate-mediated release of NO from endothelial cells immobilized in a microfluidic network without any adhesion factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.