ArticleInfection and immunity2013
Congenic strains of the filamentous form of Cryptococcus neoformans for studies of fungal morphogenesis and virulence.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 88 citations in OpenAlex.
- Homeodomain protein Sxi1α independently controls cell-cell fusion and gene expression during sexual reproduction in Cryptococcus deneoformans.PLoS genetics · 2026Article
- A conserved C2H2 zinc finger protein, Rel1, links ribosome biogenesis to sexual development and antifungal susceptibility in a ubiquitous human fungal pathogen.Applied and environmental microbiology · 2025Article
- The Zinc Finger Protein Zfp2 Regulates Cell-Cell Fusion and Virulence inJournal of fungi (Basel, Switzerland) · 2025Article
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- Homeodomain protein Sxi1α independently controls cell-cell fusion and gene expression during sexual reproduction inbioRxiv : the preprint server for biology · 2025Article
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- Identification of a protective antigen reveals the trade-off between iron acquisition and antigen exposure in a global fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Discovery of CONature microbiology · 2024Article
- Distinct effect of calorie restriction between congenic mating types of Cryptococcus neoformans.Scientific reports · 2024Article
- All hands on Dec: Treating cryptococcosis with dectin decorated liposomes loaded with antifungals.iScience · 2024Article
- Vaccination with aInfection and immunity · 2023Article
- The COMPASS Complex Regulates Fungal Development and Virulence through Histone Crosstalk in the Fungal PathogenJournal of fungi (Basel, Switzerland) · 2023Article
- Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogenProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen.Nature communications · 2022Article
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- A Velvet Transcription Factor Specifically Activates Mating through a Novel Mating-Responsive Protein in the Human Fungal Pathogen Cryptococcus deneoformans.Microbiology spectrum · 2022Article
- Article
- Dynamic genome plasticity during unisexual reproduction in the human fungal pathogen Cryptococcus deneoformans.PLoS genetics · 2021Article
- A unique cell wall synthetic response evoked by glucosamine determines pathogenicity-associated fungal cellular differentiation.PLoS genetics · 2021Article
- Factors enforcing the species boundary between the human pathogens Cryptococcus neoformans and Cryptococcus deneoformans.PLoS genetics · 2021Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Cryptococcus neoformans is an unconventional dimorphic fungus that can grow either as a yeast or in a filamentous form. To facilitate investigation of genetic factors important for its morphogenesis and pathogenicity, congenic a and α strains for a filamentous form were constructed. XL280 (α) was selected as the background strain because of its robust ability to undergo the morphological transition from yeast to the filamentous form. The MATa allele from a sequenced strain JEC20 was introgressed into the XL280 background to generate the congenic a and α pair strains. The resulting congenic strains were then used to test the impact of mating type on virulence. In both the inhalation and the intravenous infection models of murine cryptococcosis, the congenic a and α strains displayed comparable levels of high virulence. The a-α coinfections displayed equivalent virulence to the individual a or α infections in both animal models. Further analyses of the mating type distribution in a-α coinfected mice suggested no influence of a-α interactions on cryptococcal neurotropism, irrespective of the route of inoculation. Furthermore, deletion or overexpression of a known transcription factor, Znf2, in XL280 abolished or enhanced filamentation and biofilm formation, consistent with its established role. Overexpression of Znf2 in XL280 led to attenuation of virulence and a reduced abundance in the brain but not in other organs, suggesting that Znf2 might interfere with cryptococcal neurotropism upon extrapulmonary dissemination. In summary, the congenic strains provide a new resource for the exploration of the relationship in Cryptococcus between cellular morphology and pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.