ArticleBrain structure & function2014
Cellular activation in limbic brain systems during social play behaviour in rats.
Article in Brain structure & function, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 88 citations in OpenAlex.
- The nucleus accumbens to ventral pallidum pathway regulates social play behavior via sex-specific mechanisms in juvenile rats.Brain structure & function · 2026Article
- Social circuits under developmental threat: Bridging rodent and human neuroscience.Developmental review : DR · 2025Article
- Refining animal care through technology: Addressing alopecia in Jaculus jaculus with validated computer vision analysis.PloS one · 2025Article
- The effects of different types of social interactions on the electrophysiology of neurons in the nucleus accumbens in rodents.Neuroscience and biobehavioral reviews · 2024Review
- The lateral habenula integrates age and experience to promote social transitions in developing rats.Cell reports · 2024Article
- Patterns of neuronal activation following ethanol-induced social facilitation and social inhibition in adolescent cFos-LacZ male and female rats.Behavioural brain research · 2024Article
- Sex differences in the structure and function of the vasopressin system in the ventral pallidum are associated with the sex-specific regulation of social play behavior in juvenile rats.Hormones and behavior · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.bioRxiv : the preprint server for biology · 2024Article
- Communal nesting shapes the sex-dependent glutamatergic response to early life stress in the rat prefrontal cortex.Frontiers in psychiatry · 2024Article
- Psychostimulants and social behaviors.Frontiers in pharmacology · 2024Review
- Social behavior and neuronal activation in adolescent female Fos-LacZ transgenic rats: Impact of acute ethanol challenge and baseline levels of social preference.Alcohol (Fayetteville, N.Y.) · 2023Article
- The medial preoptic area and its projections to the ventral tegmental area and the periaqueductal gray are activated in response to social play behavior in juvenile rats.Behavioral neuroscience · 2023Article
- Social play behavior shapes the development of prefrontal inhibition in a region-specific manner.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Amygdala circuit transitions supporting developmentally-appropriate social behavior.Neurobiology of learning and memory · 2023Review
- Comparing the ontogeny, neurobiology, and function of social play in hamsters and rats.Neuroscience and biobehavioral reviews · 2023Review
- Social Play Behavior Is Critical for the Development of Prefrontal Inhibitory Synapses and Cognitive Flexibility in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Maternal allergic inflammation in rats impacts the offspring perinatal neuroimmune milieu and the development of social play, locomotor behavior, and cognitive flexibility.Brain, behavior, and immunity · 2021Article
- Modulating the Activity of the VMPFC With tDCS Alters the Social Framing Effect.Frontiers in behavioral neuroscience · 2021Article
- Distinct dynamics of social motivation drive differential social behavior in laboratory rat and mouse strains.Nature communications · 2020Article
- Mu opioid receptors in the medial preoptic area govern social play behavior in adolescent male rats.Genes, brain, and behavior · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Positive social interactions during the juvenile and adolescent phases of life are essential for proper social and cognitive development in mammals, including humans. During this developmental period, there is a marked increase in peer-peer interactions, signified by the abundance of social play behaviour. Despite its importance for behavioural development, our knowledge of the neural underpinnings of social play behaviour is limited. Therefore, the purpose of this study was to map the neural circuits involved in social play behaviour in rats. This was achieved by examining cellular activity after social play using the immediate early gene c-Fos as a marker. After a session of social play behaviour, pronounced increases in c-Fos expression were observed in the medial prefrontal cortex, medial and ventral orbitofrontal cortex, dorsal striatum, nucleus accumbens core and shell, lateral amygdala, several thalamic nuclei, dorsal raphe and the pedunculopontine tegmental nucleus. Importantly, the cellular activity patterns after social play were topographically organized in this network, as indicated by play-specific correlations in c-Fos activity between regions with known direct connections. These correlations suggest involvement in social play behaviour of the projections from the medial prefrontal cortex to the striatum, and of amygdala and monoaminergic inputs to frontal cortex and striatum. The analyses presented here outline a topographically organized neural network implicated in processes such as reward, motivation and cognitive control over behaviour, which mediates social play behaviour in rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.