ArticleMolecular systems biology2013
Nucleotide degradation and ribose salvage in yeast.
Article in Molecular systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 74 citations in OpenAlex.
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- Phospholipid biosynthesis modulates nucleotide metabolism and reductive capacity.Nature chemical biology · 2025Article
- A fungal metabolic regulator underlies infectious synergism during Candida albicans-Staphylococcus aureus intra-abdominal co-infection.Nature communications · 2024Article
- Reversing the directionality of reactions between non-oxidative pentose phosphate pathway and glycolytic pathway boosts mycosporine-like amino acid production in Saccharomyces cerevisiae.Microbial cell factories · 2024Article
- Rapid discrimination between wild and cultivatedCurrent research in food science · 2024Article
- Effects of Four Organic Carbon Sources on the Growth and Astaxanthin Accumulation ofLife (Basel, Switzerland) · 2023Article
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- Quantitative modeling of pentose phosphate pathway response to oxidative stress reveals a cooperative regulatory strategy.iScience · 2022Article
- Initiation of cytosolic plant purine nucleotide catabolism involves a monospecific xanthosine monophosphate phosphatase.Nature communications · 2021Article
- Application of Metabolomics in the Study of Starvation-Induced Autophagy inJournal of fungi (Basel, Switzerland) · 2021Article
- Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism.EMBO molecular medicine · 2021Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Nucleotide degradation is a universal metabolic capability. Here we combine metabolomics, genetics and biochemistry to characterize the yeast pathway. Nutrient starvation, via PKA, AMPK/SNF1, and TOR, triggers autophagic breakdown of ribosomes into nucleotides. A protein not previously associated with nucleotide degradation, Phm8, converts nucleotide monophosphates into nucleosides. Downstream steps, which involve the purine nucleoside phosphorylase, Pnp1, and pyrimidine nucleoside hydrolase, Urh1, funnel ribose into the nonoxidative pentose phosphate pathway. During carbon starvation, the ribose-derived carbon accumulates as sedoheptulose-7-phosphate, whose consumption by transaldolase is impaired due to depletion of transaldolase's other substrate, glyceraldehyde-3-phosphate. Oxidative stress increases glyceraldehyde-3-phosphate, resulting in rapid consumption of sedoheptulose-7-phosphate to make NADPH for antioxidant defense. Ablation of Phm8 or double deletion of Pnp1 and Urh1 prevent effective nucleotide salvage, resulting in metabolite depletion and impaired survival of starving yeast. Thus, ribose salvage provides means of surviving nutrient starvation and oxidative stress.
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