Evidence map›Paper›PMID 23670533›Full record

ArticleMarine drugs2013

Synthesis, characterization, and antibacterial activity of cross-linked chitosan-glutaraldehyde.

Bin Li, Chang-Lin Shan, Qing Zhou, Yuan Fang, Yang-Li Wang, Fei Xu, Li-Rong Han, Muhammad Ibrahim, Long-Biao Guo, Guan-Lin Xie and 1 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 292 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Application of Chitosan@FeSensors (Basel, Switzerland) · 2025
    Article
  12. Article
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  14. Article
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  17. Review
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Bin LiState Key Laboratory of Rice Biology, Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China. libin0571@zju.edu.cn
Chang-Lin Shan
Qing Zhou
Yuan Fang
Yang-Li Wang
Fei Xu
Li-Rong Han
Muhammad Ibrahim
Long-Biao Guo
Guan-Lin Xie
Guo-Chang Sun
China National Rice Research Institute · CNZheJiang Academy of Agricultural Sciences · CNZhejiang University · CNNorth West Agriculture and Forestry University · CNState Key Laboratory of Rice BiologyZhejiang Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This present study deals with synthesis, characterization and antibacterial activity of cross-linked chitosan-glutaraldehyde. Results from this study indicated that cross-linked chitosan-glutaraldehyde markedly inhibited the growth of antibiotic-resistant Burkholderia cepacia complex regardless of bacterial species and incubation time while bacterial growth was unaffected by solid chitosan. Furthermore, high temperature treated cross-linked chitosan-glutaraldehyde showed strong antibacterial activity against the selected strain 0901 although the inhibitory effects varied with different temperatures. In addition, physical-chemical and structural characterization revealed that the cross-linking of chitosan with glutaraldehyde resulted in a rougher surface morphology, a characteristic Fourier transform infrared (FTIR) band at 1559 cm⁻¹, a specific X-ray diffraction peak centered at 2θ = 15°, a lower contents of carbon, hydrogen and nitrogen, and a higher stability of glucose units compared to chitosan based on scanning electron microscopic observation, FTIR spectra, X-ray diffraction pattern, as well as elemental and thermo gravimetric analysis. Overall, this study indicated that cross-linked chitosan-glutaraldehyde is promising to be developed as a new antibacterial drug.

Indexed as

Anti-Bacterial AgentsBurkholderia cepaciaChitosanCross-Linking ReagentsDrug Resistance, BacterialGlutaralHot TemperatureMicroscopy, Electron, ScanningSpectroscopy, Fourier Transform InfraredTemperatureThermogravimetryTime FactorsX-Ray DiffractionAnti-Bacterial AgentsChitosanCross-Linking ReagentsGlutaral

Identifiers

PMID23670533
PMCPMC3707160
OpenAlexW1971680873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.