ReviewFamilial cancer2013
100 years Lynch syndrome: what have we learned about psychosocial issues?
Review in Familial cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- The evolution of hereditary cancer genetic counselling: mainstreaming, service redesign and patient experience in Lynch syndrome.Familial cancer · 2026Review
- Interventions to support patients with sharing genetic test results with at-risk relatives: a synthesis without meta-analysis (SWiM).European journal of human genetics : EJHG · 2023Review
- Testing and extending strategies for identifying genetic disease-related encounters in pediatric patients.Genetics in medicine : official journal of the American College of Medical Genetics · 2022Article
- What would I do? Perspectives on the factors underlying Lynch syndrome genetic testing and results sharing decisions for high-risk colorectal cancer patients.Psycho-oncology · 2022Article
- Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome.Scientific reports · 2020Article
- Information exchange between patients with Lynch syndrome and their genetic and non-genetic health professionals: whose responsibility?Journal of community genetics · 2019Article
- Unsolicited information letters to increase awareness of Lynch syndrome and familial colorectal cancer: reactions and attitudes.Familial cancer · 2019Article
- How does genetic risk information for Lynch syndrome translate to risk management behaviours?Hereditary cancer in clinical practice · 2017Article
- Is there evidence that we should screen the general population for Lynch syndrome with genetic testing? A systematic review.Pharmacogenomics and personalized medicine · 2017Review
- Observational
- Long-term psychosocial and behavioral adjustment in individuals receiving genetic test results in Lynch syndrome.Clinical genetics · 2015Article
- Prevalence and correlates of receiving and sharing high-penetrance cancer genetic test results: findings from the Health Information National Trends Survey.Public health genomics · 2015Article
- Balancing life with an increased risk of cancer: lived experiences in healthy individuals with Lynch syndrome.Journal of genetic counseling · 2014Article
- Epithelial-mesenchymal transition in colorectal cancer tissue of patients with Lynch syndrome.World journal of gastroenterology · 2014Article
- From genetic counseling to "genomic counseling".Molecular genetics & genomic medicine · 2013Article
- Psychological impact of von Hippel-Lindau genetic screening in patients with a previous history of hemangioblastoma of the central nervous system.Journal of psychosocial oncologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the care of patients with Lynch Syndrome (LS), a range of psychosocial issues are encountered, which significantly affect patient outcomes. A brief historical background of 'psycho-onco-genetics' (the domain where psychology, oncology and genetics meet) in relation to LS is presented, followed by an overview of important psychosocial issues identified in the past 20 years. The identification of mismatch repair genes in 1993-1994 made possible genetic counseling and testing for patients who had cancer and for potentially high-risk relatives without cancer. At that time, concerns were raised about the potentially negative psychosocial impact of predictive genetic testing. Since 1993, a large number of studies have been conducted to investigate the possible psychosocial benefits and limitations of such testing. This article presents an overview of: the uptake of and motivations for genetic testing, its psychosocial impact (e.g. psychological adaptation, impact on risk perception and self-concept, and concerns about, and experiences of, genetic discrimination), psychological screening instruments, adherence to and decision-making about preventive strategies, family communication, lifestyle changes, reproductive technology utilization, and professional psychosocial support needs of members of families with LS. Finally, challenges for the future are discussed, including population screening and genomic testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.