SynthesisCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2013
Associations of job strain and lifestyle risk factors with risk of coronary artery disease: a meta-analysis of individual participant data.
Synthesis in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 6 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 6 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Psychosocial work exposures and health outcomes: a meta-review of 72 literature reviews with meta-analysis.Scandinavian journal of work, environment & health · 2021Pooled it
- Computer-based versus in-person interventions for preventing and reducing stress in workers.The Cochrane database of systematic reviews · 2017Pooled it
- A systematic review of studies in the contributions of the work environment to ischaemic heart disease development.European journal of public health · 2016Pooled it
- Pooled it
- Diagnostic Value of Serum YKL-40 Level for Coronary Artery Disease: A Meta-Analysis.Journal of clinical laboratory analysis · 2016Pooled it
- Job strain as a risk factor for type 2 diabetes: a pooled analysis of 124,808 men and women.Diabetes care · 2014Pooled it
- Unravelling the role of inflammatory markers in coronary artery disease risk via association, mediation and prediction analyses.Journal of global health · 2026Article
- Coronary Heart Disease Attributable to Psychosocial Stressors at Work.JACC. Advances · 2025Article
- Effects of rumination and post-traumatic growth on health behavior among older patients with coronary heart disease.Scientific reports · 2025Article
- The impact of alternative arrangements, contingent jobs, and work secured through an app on the well-being of working age adults: Results from the California Work and Health Survey.American journal of industrial medicine · 2024Article
- The Relationship between Job Strain and Ischemic Heart Disease Mediated by Endothelial Dysfunction Markers and Imaging.Medicina (Kaunas, Lithuania) · 2024Article
- Development of a Flexible Sensor-Integrated Tissue Patch to Monitor Early Organ Rejection Processes Using Impedance Spectroscopy.Biosensors · 2024Article
- Increased job strain and cardiovascular disease mortality: a prospective cohort study in U.S. workers.Industrial health · 2023Article
- Do changes in working hours increase stress in Japanese white-collar workers?Frontiers in public health · 2023Article
- Persistence to Medications for Benign Prostatic Hyperplasia/Benign Prostatic Obstruction-Associated Lower Urinary Tract Symptoms in the ASL TO4 Regione Piemonte (Italy).Healthcare (Basel, Switzerland) · 2022Article
- Increased all-cause mortality following occupational injury: a comparison of two states.Occupational and environmental medicine · 2022Article
- The associations of job strain and leisure-time physical activity with the risk of hypertension: the population-based Midlife in the United States cohort study.Epidemiology and health · 2022Article
- The COVID-19 Study of Healthcare and Support Personnel (CHAMPS): Protocol for a Longitudinal Observational Study.JMIR research protocols · 2021Article
- Relationship of work-related stress with obesity among Brazilian female shift workers.Public health nutrition · 2021Article
- Spontaneous Coronary Artery Dissection: Does Being Unemployed Matter? Insights from the GSCAD Registry.Current cardiology reviews · 2021Article
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Authors and funding
34 authors at 18 institutions in 8 countries.
Funding
Abstract
backgroundIt is unclear whether a healthy lifestyle mitigates the adverse effects of job strain on coronary artery disease. We examined the associations of job strain and lifestyle risk factors with the risk of coronary artery disease.
methodsWe pooled individual-level data from 7 cohort studies comprising 102 128 men and women who were free of existing coronary artery disease at baseline (1985-2000). Questionnaires were used to measure job strain (yes v. no) and 4 lifestyle risk factors: current smoking, physical inactivity, heavy drinking and obesity. We grouped participants into 3 lifestyle categories: healthy (no lifestyle risk factors), moderately unhealthy (1 risk factor) and unhealthy (2-4 risk factors). The primary outcome was incident coronary artery disease (defined as first nonfatal myocardial infarction or cardiac-related death).
resultsThere were 1086 incident events in 743,948 person-years at risk during a mean follow-up of 7.3 years. The risk of coronary artery disease among people who had an unhealthy lifestyle compared with those who had a healthy lifestyle (hazard ratio [HR] 2.55, 95% confidence interval [CI] 2.18-2.98; population attributable risk 26.4%) was higher than the risk among participants who had job strain compared with those who had no job strain (HR 1.25, 95% CI 1.06-1.47; population attributable risk 3.8%). The 10-year incidence of coronary artery disease among participants with job strain and a healthy lifestyle (14.7 per 1000) was 53% lower than the incidence among those with job strain and an unhealthy lifestyle (31.2 per 1000).
interpretationThe risk of coronary artery disease was highest among participants who reported job strain and an unhealthy lifestyle; those with job strain and a healthy lifestyle had half the rate of disease. A healthy lifestyle may substantially reduce disease risk among people with job strain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.