ArticleAnnals of oncology : official journal of the European Society for Medical Oncology2013
Consumption of fish and meats and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition (EPIC).
Article in Annals of oncology : official journal of the European Society for Medical Oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Association of meat consumption with the risk of gastrointestinal cancers: a systematic review and meta-analysis.BMC cancer · 2023Pooled it
- Associations between food groups and liver cancer: a systematic review and meta-analysis of observational studies.Nutrition journal · 2023Pooled it
- Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies.European journal of epidemiology · 2021Pooled it
- Pooled it
- Fish intake and risk of liver cancer: a meta-analysis.PloS one · 2015Pooled it
- Prophylactic Effects of Dietary Patterns and Indexes, Nutrition and Lifestyle on Hepatocellular Carcinoma.Annals of surgical oncology · 2026Review
- The Role of miRNA-21 in the Metastasis of Hepatocellular Carcinoma as a Therapeutic Target.International journal of hematology-oncology and stem cell research · 2026Review
- Lifestyle factors in hepatocellular carcinoma: From pathogenesis to prognosis.World journal of clinical oncology · 2025Review
- The associations between dairy intake and chronic liver disease mortality and liver cancer incidence: a prospective cohort study.The American journal of clinical nutrition · 2025Article
- Meat consumption and risk of hepatobiliary cancers in the National Institutes of Health-AARP Diet and Health Study.JNCI cancer spectrum · 2025Article
- Causal associations between dietary habits and liver cancer risk: a two-sample Mendelian randomization study.Discover oncology · 2025Article
- Microfluidic biosensors for biomarker detection in body fluids: a key approach for early cancer diagnosis.Biomarker research · 2024Review
- Dietary patterns and hepatocellular carcinoma risk: a systematic review and meta-analysis of cohort and case-control studies.Nutrition & metabolism · 2024Review
- Diet, lifestyle factors, comorbidities, and hepatocellular carcinoma risk in a middle eastern country: a case-control study.BMC cancer · 2024Article
- Sex-specific impact of dietary patterns on liver cancer incidence: updated results from two population-based cohort studies in China.European journal of nutrition · 2024Article
- Prevention of colitis-induced liver oxidative stress and inflammation in a transgenic mouse model with increased omega-3 polyunsaturated fatty acids.Redox biology · 2023Article
- Dietary inflammatory and insulinemic potential, risk of hepatocellular carcinoma, and chronic liver disease mortality.JNCI cancer spectrum · 2023Article
- The relationship between processed meat, red meat, and risk of types of cancer: A Mendelian randomization study.Frontiers in nutrition · 2022Article
- Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality.Nature communications · 2021Article
- Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC.Biomedicines · 2021Review
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Authors and funding
44 authors at 20 institutions in 11 countries.
Funding
Abstract
backgroundWhile higher intake of fish and lower consumption of red/processed meats have been suggested to play a protective role in the etiology of several cancers, prospective evidence for hepatocellular carcinoma (HCC) is limited, particularly in Western European populations.
methodsThe associations of fish and meats with HCC risk were analyzed in the EPIC cohort. Between 1992 and 2010, 191 incident HCC were identified among 477 206 participants. Baseline diet was assessed using validated dietary questionnaires. A single 24-h diet recall from a cohort subsample was used for calibration. Multivariable proportional hazard regression was utilized to estimate hazard ratios (HR) and 95% confidence intervals (CI). In a nested case-control subset (HCC = 122), HBV/HCV status and liver function biomarkers were measured.
resultsHCC risk was inversely associated with intake of total fish (per 20 g/day increase, HR = 0.83, 95% CI 0.74-0.95 and HR = 0.80, 95% CI 0.69-0.97 before and after calibration, respectively). This inverse association was also suggested after adjusting for HBV/HCV status and liver function score (per 20-g/day increase, RR = 0.86, 95% CI 0.66-1.11 and RR = 0.74, 95% CI 0.50-1.09, respectively) in a nested case-control subset. Intakes of total meats or subgroups of red/processed meats, and poultry were not associated with HCC risk.
conclusionsIn this large European cohort, total fish intake is associated with lower HCC risk.
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