Evidence map›Paper›PMID 23669732›Full record

ArticleJournal of pediatric hematology/oncology2014

Evaluation of the retinoids with cisplatin and vincristine in xenograft models of neuroblastoma.

Robin E Norris, Vu T Nguyen, Peter C Adamson

Abstract read
In one paragraph

Article in Journal of pediatric hematology/oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. The Impact of Isotretinoin on Lipid Profile: a Systematic Review.Annals of medicine and surgery (2012) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Robin E Norris*Divison of Pediatric Hematology/Oncology, Rainbow Babies and Children's Hospital, Cleveland, OH †Division of Clinical Pharmacology & Therapeutics, Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA.
Vu T Nguyen
Peter C Adamson
Children's Hospital of Philadelphia · USRainbow Babies & Children's Hospital · US

Funding

Neuroblastoma Biology and TherapyP01CA097323 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI BRODEUR, GARRETT M · 2003 to 2007
$10.6M
NCI NIH HHS P01 CA097323NCI NIH HHS P01CA097323
6 · The paper itself

Abstract

Retinoids have been studied for the treatment of children with neuroblastoma for >25 years. Posttransplant administration of isotretinoin is standard of care for children with high-risk neuroblastoma, whereas fenretinide remains investigational. Previous preclinical studies have evaluated the interaction of retinoids and cytotoxic agents with conflicting results. We evaluated the schedule-dependent interaction of the cytotoxic agents, vincristine and cisplatin, with the retinoids, isotretinoin and fenretinide, in xenograft models of neuroblastoma. Concomitant administration of isotretinoin or fenretinide with the cytotoxic agents did not result in any clear potentiation of cytotoxicity.

Indexed as

AnimalsAntineoplastic AgentsAntineoplastic Agents, PhytogenicAntineoplastic Combined Chemotherapy ProtocolsCisplatinDrug InteractionsFemaleMiceMice, SCIDNervous System NeoplasmsNeuroblastomaRetinoidsVincristineXenograft Model Antitumor AssaysAntineoplastic AgentsAntineoplastic Agents, PhytogenicCisplatinRetinoidsVincristine

Identifiers

PMID23669732
PMCPMC3766379
OpenAlexW2324940702

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.