ArticleNeuroscience letters2013
α-Synuclein mutations cluster around a putative protein loop.
Article in Neuroscience letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Amyloid accelerator polyphosphate fits as the mystery density in α-synuclein fibrils.PLoS biology · 2024Article
- Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS.Protein science : a publication of the Protein Society · 2024Article
- Strategies for modeling aging and age-related diseases.npj aging · 2024Review
- Passive Immunization in Alpha-Synuclein Preclinical Animal Models.Biomolecules · 2022Review
- Predictive Modeling of Neurotoxic α-Synuclein Polymorphs.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Similarity of the non-amyloid-β component and C-terminal tail of monomeric and tetrameric alpha-synuclein with 14-3-3 sigma.Computational and structural biotechnology journal · 2021Article
- Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation.Neural regeneration research · 2020Review
- Endogenous alpha-synuclein monomers, oligomers and resulting pathology: let's talk about the lipids in the room.NPJ Parkinson's disease · 2019Review
- Rationally Designed Variants of α-Synuclein Illuminate ItsFrontiers in neuroscience · 2018Review
- α-Synuclein is a Novel Microtubule Dynamase.Scientific reports · 2016Article
- Phosphatidylethanolamine Metabolism in Health and Disease.International review of cell and molecular biology · 2016Review
- Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease.PloS one · 2016Article
- Parkinson's disease: From human genetics to clinical trials.Science translational medicine · 2015Article
- Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation.Molecular neurodegeneration · 2015Article
- From intrinsically disordered protein to context-dependent folding: The α-synuclein tetramer is teased out of hiding.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.Nature communications · 2015Article
- Seeking a mechanism for the toxicity of oligomeric α-synuclein.Biomolecules · 2015Review
- Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.Biochemistry · 2015Article
- α-synuclein multimers cluster synaptic vesicles and attenuate recycling.Current biology : CB · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
With the recent identification of two new pathogenic mutations in α-synuclein, we map the five known pathogenic mutations onto the best available models of the protein structure. We show that four of the five mutations map to a potential fold in the protein with the exception being the A30P mutation in which the substitution would be expected to have a profound effect on protein structure. We discuss this localisation in terms of the proposed mechanisms for mutation pathogenicity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.