ArticleJOP : Journal of the pancreas2013
Duration of diabetes and pancreatic cancer in a case-control study in the Midwest and the Iowa Women's Health Study (IWHS) cohort.
Article in JOP : Journal of the pancreas, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Long-Term Diabetes Mellitus Is Associated with an Increased Risk of Pancreatic Cancer: A Meta-Analysis.PloS one · 2015Pooled it
- Diabetes-Related Complications and Pancreatic Cancer Incidence in the Multiethnic Cohort.JNCI cancer spectrum · 2020Article
- Urban vs rural residency and allergy prevalence among adult women: Iowa Women's Health Study.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Article
- Role of survivor bias in pancreatic cancer case-control studies.Annals of epidemiology · 2016Article
- Type 2 diabetes mellitus is associated with increased risk of pancreatic cancer: A veteran administration registry study.SAGE open medicine · 2016Article
- Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium.Annals of oncology : official journal of the European Society for Medical Oncology · 2014Article
- Risk factors and therapeutic targets in pancreatic cancer.Frontiers in oncology · 2013Review
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Abstract
contextStudies have shown a relationship between history of diabetes and the risk of pancreatic cancer; however, the temporal relation between diabetes and pancreatic cancer is not clearly established.
objectivesDiabetes and diabetes duration were examined in relation to pancreatic cancer in a population-based case-control study and prospective cohort.
methodsCase-control study: pancreatic cancer cases (n=200) from the Midwest were frequency matched by age and sex to population controls (n=673). Logistic regression yielded odds ratios (ORs) and 95% confidence intervals (95% CI). Iowa Women's Health Study (IWHS) cohort: 292 incident pancreatic cancer cases occurred between 1986-2008 among 36,084 post-menopausal, initially cancer-free women. Diabetes status and diagnosis age were ascertained at baseline and follow-ups. Proportional hazards regression yielded hazard ratios (HR, 95% CI) for pancreatic cancer in relation to baseline diabetes. Time-dependent analyses accounted for diabetes diagnosed after baseline. A nested-case control analysis assessed diabetes duration as a risk factor.
resultsIn the case-control study, compared to participants without diabetes, the multivariate ORs (95% CI) for pancreatic cancer were 2.35 (1.24-4.47) for those with diabetes and 4.00 (0.94-16.9), 2.79 (0.97-8.04), and 2.40 (0.97-5.98) for diabetes durations of 2-5 years, 5.1-10 years, and more than 10 years, respectively. In IWHS, compared to no diabetes, multivariate-adjusted HRs for pancreatic cancer were 1.86 (1.23-2.83) for baseline diabetes and 1.94 (1.40-2.69) adding diabetes during follow-up. In an IWHS nested case-control analysis, ORs were 1.70 (0.78-3.67), 2.62 (1.48-4.65), and 2.10 (1.36-3.24) for diabetes durations of 2-5 years, 5.1-10 years and more than 10 years, respectively, versus no diabetes.
conclusionsDiabetes is associated with pancreatic cancer risk and this is similar across different duration categories.
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