ArticleThe Journal of experimental medicine2013
CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1β and TNF.
Article in The Journal of experimental medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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Who cites it
33 citing papers in PubMed, 55 citations in OpenAlex.
- Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases.Acta pharmaceutica Sinica. B · 2025Review
- CD47: an immunoregulatory nexus in liver and gastrointestinal disorders.eGastroenterology · 2025Review
- Mucosal Single-Cell Profiling of Crohn's-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets.Gastroenterology · 2024Article
- Single-Cell and Spatial Multi-omics Reveal Interferon Signaling in the Pathogenesis of Perianal Fistulizing Crohn's Disease.bioRxiv : the preprint server for biology · 2024Article
- The expression of signal regulatory protein alpha (SIRPα) in periodontal cells and tissue.Acta odontologica Scandinavica · 2024Article
- Exploration of the combined role of immune checkpoints and immune cells in the diagnosis and treatment of ankylosing spondylitis: a preliminary study immune checkpoints in ankylosing spondylitis.Arthritis research & therapy · 2024Article
- The Role of the Lymphatic System in the Pathogenesis and Treatment of Inflammatory Bowel Disease.International journal of molecular sciences · 2022Review
- Soluble SIRP-Alpha Promotes Murine Acute Lung Injury Through Suppressing Macrophage Phagocytosis.Frontiers in immunology · 2022Article
- Loss of CD47 alters CD8+ T cell activationOncoimmunology · 2022Article
- IL-27 Derived From Macrophages Facilitates IL-15 Production and T Cell Maintenance Following Allergic Hypersensitivity Responses.Frontiers in immunology · 2021Article
- Unexpected mechanism of colitis amelioration by artesunate, a natural product from Artemisia annua L.Inflammopharmacology · 2020Article
- Review
- Transcriptomic Analysis and High-dimensional Phenotypic Mapping of Mononuclear Phagocytes in Mesenteric Lymph Nodes Reveal Differences Between Ulcerative Colitis and Crohn's Disease.Journal of Crohn's & colitis · 2020Article
- IL-12 and Mucosal CD14+ Monocyte-Like Cells Induce IL-8 in Colonic Memory CD4+ T Cells of Patients With Ulcerative Colitis but not Crohn's Disease.Journal of Crohn's & colitis · 2020Article
- Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease.Frontiers in immunology · 2020Review
- Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo.Nature communications · 2019Article
- Natural Killer Cell Recruitment and Activation Are Regulated by CD47 Expression in the Tumor Microenvironment.Cancer immunology research · 2019Article
- Increased lymphocyte activation and atherosclerosis in CD47-deficient mice.Scientific reports · 2019Article
- Two distinct colonic CD14Mucosal immunology · 2019Article
- Recruitment of activated neutrophils correlates with disease severity in adult Crohn's disease.Clinical and experimental immunology · 2019Article
Corrections and comments
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Authors and funding
28 authors at 4 institutions in 4 countries.
Funding
Abstract
In mice, the transfer of CD172a(+) (SIRP-α) dendritic cells (DCs) elicits T cell-driven colitis, whereas treatment with CD47-Fc protein, a CD172a-binding agent, confers protection. The aim of this study was to elucidate the nature and functional properties of human CD172a(+) DCs in chronic intestinal inflammation. Here, we show that CD172a(+)CD11c(+) cells accumulate in the mesenteric lymph nodes (mLNs) and inflamed intestinal mucosa in patients with Crohn's disease (CD). These cells are distinct from resident DCs and may coexpress markers typically associated with monocyte-derived inflammatory DCs such as CD14 and/or DC-SIGN, E-Cadherin, and/or CX3CR1. Spontaneous IL-1β and TNF production by HLA-DR(+) cells in CD tissues is restricted to those expressing CD172a. An avidity-improved CD47 fusion protein (CD47-Var1) suppresses the release of a wide array of inflammatory cytokines by CD172a(+) cells, which may include HLA-DR(-)CD172a(+) neutrophils, in inflamed colonic explant cultures and impairs the ability of HLA-DR(+)CD172a(+) cells to activate memory Th17 but not Th1 responses in mLNs. In conclusion, targeting CD172a(+) cells may represent novel therapeutic perspectives for patients with CD.
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