ArticleAntimicrobial agents and chemotherapy2013
Glyceryl trinitrate complements citrate and ethanol in a novel antimicrobial catheter lock solution to eradicate biofilm organisms.
Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Antimicrobial lock therapy in central-line associated bloodstream infections: a systematic review.Infection · 2015Pooled it
- Relocating Glyceryl Trinitrate as an Anti-Virulence Agent againstMicroorganisms · 2023Article
- Diminishing the Pathogenesis of the Food-Borne PathogenBiology · 2023Article
- Antifungal lock therapy: an eternal promise or an effective alternative therapeutic approach?Letters in applied microbiology · 2022Review
- Sodium Citrate Alleviates Virulence inMicroorganisms · 2022Article
- Pharmacokinetics, Tissue Distribution, and Efficacy of VIO-001 (Meropenem/Piperacillin/Tazobactam) for Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia in Immunocompetent Rabbits with Chronic Indwelling Vascular Catheters.Antimicrobial agents and chemotherapy · 2021Article
- Synthesis, Cytotoxicity Evaluation, and Antifungal Activity of Novel Nitroglycerin Derivatives against ClinicalIranian journal of public health · 2021Article
- Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections.F1000Research · 2021Review
- Glyceryl trinitrate blocks staphyloxanthin and biofilm formation inAfrican health sciences · 2019Article
- Non-Antibiotic Antimicrobial Catheter Lock Solutions in Patients on Home Parenteral Nutrition.Nutrients · 2018Review
- Comparative Efficacies of Antimicrobial Catheter Lock Solutions for Fungal Biofilm Eradication in an in Vitro Model of Catheter-Related Fungemia.Journal of fungi (Basel, Switzerland) · 2017Article
- Glyceryl trinitrate is a novel inhibitor of quorum sensing inAfrican health sciences · 2016Article
- In Vitro Assessment of the Antimicrobial Efficacy of Optimized Nitroglycerin-Citrate-Ethanol as a Nonantibiotic, Antimicrobial Catheter Lock Solution for Prevention of Central Line-Associated Bloodstream Infections.Antimicrobial agents and chemotherapy · 2016Article
- Polyphenolic extract from maple syrup potentiates antibiotic susceptibility and reduces biofilm formation of pathogenic bacteria.Applied and environmental microbiology · 2015Article
- Caprylic acid and glyceryl trinitrate combination for eradication of biofilm.Antimicrobial agents and chemotherapy · 2015Article
- Flushing and Locking of Venous Catheters: Available Evidence and Evidence Deficit.Nursing research and practice · 2015Review
- The Role of Antifungals against Candida Biofilm in Catheter-Related Candidemia.Antibiotics (Basel, Switzerland) · 2014Review
- Ventricular shunt infections: immunopathogenesis and clinical management.Journal of neuroimmunology · 2014Review
- Quasi-experimental study of sodium citrate locks and the risk of acute hemodialysis catheter infection among critically ill patients.Antimicrobial agents and chemotherapy · 2014Article
- Antibiofilm Effect of Octenidine Hydrochloride on Staphylococcus aureus, MRSA and VRSA.Pathogens (Basel, Switzerland) · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial catheter lock therapy is practiced to prevent lumenal-sourced infections of central venous catheters. Citrate has been used clinically as an anticoagulant in heparin-free catheter locks. Ethanol has also been widely studied as an antimicrobial lock solution component. This study reports on the synergy of glyceryl trinitrate (GTN) with citrate and ethanol in rapidly eradicating methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, Pseudomonas aeruginosa, and Candida albicans biofilms in an in vitro model for catheter biofilm colonization. GTN has a long history of intravenous use as a hypotensive agent. It is potentially attractive as a component of a catheter lock solution because its physiologic half-life is quite short and its metabolic pathways are known. A lock containing 7% citrate and 20% ethanol required 0.01% GTN to fully eradicate biofilms of all test organisms within 2 h in the model. This GTN concentration is below the levels where clinically significant hypotensive effects are expected.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.