Evidence map›Paper›PMID 23669364›Full record

ArticleFEBS letters2013

A Trp199Glu MauG variant reveals a role for Trp199 interactions with pre-methylamine dehydrogenase during tryptophan tryptophylquinone biosynthesis.

Nafez Abu Tarboush, Lyndal M R Jensen, Carrie M Wilmot, Victor L Davidson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Nafez Abu TarboushBiochemistry and Physiology Department, College of Medicine, The University of Jordan, Amman 11942, Jordan.
Lyndal M R Jensen
Carrie M Wilmot
Victor L Davidson
University of Minnesota · USUniversity of Central Florida · USUniversity of Jordan · JO

Funding

Catalysis and biogenesis in methylamine dehydrogenaseR01GM066569 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WILMOT, CAROLINE MARY · 2002 to 2015
$4.0M
Structure Function & Biosynthesis of Respiratory EnzymesR37GM041574 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI DAVIDSON, VICTOR L · 2009 to 2018
$3.4M
STRUCTURE/FUNCTION &BIOSYNTHESIS OF RESPIRATORY ENZYMESR01GM041574 · NIGMS · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI DAVIDSON, VICTOR L · 1988 to 2008
$2.7M
NCI NIH HHS Y1-CO-1020NIGMS NIH HHS GM41574NIGMS NIH HHS GM66569NIGMS NIH HHS R01 GM041574NIGMS NIH HHS R01 GM066569NIGMS NIH HHS R37 GM041574NIGMS NIH HHS Y1-GM-1104
6 · The paper itself

Abstract

MauG catalyzes posttranslational modifications of a methylamine dehydrogenase precursor (preMADH) to complete the biosynthesis of its protein-derived tryptophan tryptophylquinone (TTQ) cofactor. Trp199 is present at the site of interaction between MauG and preMADH and is critical to this process as it mediates hole hopping during the inter-protein electron transfer that is required for catalysis. Trp199 was converted to Glu and the structure and reactivity of the W199E/preMADH complex were characterized. The results reveal that the nature of residue 199 is also important for productive complex formation between preMADH and MauG.

Indexed as

Mutagenesis, Site-DirectedMutationBacterial ProteinsBenzoquinonesElectron TransportEnzyme PrecursorsIndolequinonesIronModels, MolecularOxidoreductases Acting on CH-NH Group DonorsParacoccus denitrificansProtein BindingProtein ConformationTryptophanBacterial ProteinsBenzoquinonesEnzyme PrecursorsIndolequinonesIronmethylamine dehydrogenaseOxidoreductases Acting on CH-NH Group DonorsquinoneTryptophantryptophan tryptophylquinone

Identifiers

PMID23669364
PMCPMC3747028
OpenAlexW1996800121

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.